• Gene id: 8666

Gene Summary

• Gene Symbol: EIF3G   Gene   UCSC   Ensembl
• Aliases: EIF3-P42, EIF3S4, eIF3-delta, eIF3-p44
• Gene name: eukaryotic translation initiation factor 3 subunit G
• Alternate names: eukaryotic translation initiation factor 3 subunit G, eukaryotic translation initiation factor 3 RNA-binding subunit, eukaryotic translation initiation factor 3 subunit p42, eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa,
• Gene location: 19p13.2 (70853238: 71053657)     Exons: 21     NC_000015.10
• Gene summary(Entrez): This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A m
• OMIM: 603913

Protein Summary

• Protein general information: O75821  
  • Name: Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA binding subunit) (eIF 3 RNA binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF 3 delta) (eIF3 p42) (eIF3 p44)
  • Length: 320  
  • Mass: 35611
• Sequence:

  MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDED
  GKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLK
  GQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRR
  GESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGV
  SGFGYDHLILNVEWAKPSTN

• Structural information:
  • Protein Domains: (239..31-)
    (/note="RRM-)
    (/evidence="ECO:0000255|HAMAP-Rule:MF_03006"-)
  • Interpro: IPR017334  IPR024675  IPR034240  IPR012677  IPR035979   IPR000504  
  • Prosite: PS50102
  • CDD: cd12933 cd12408
  • PDB: 2CQ0 2MJC 5K0Y
  • PDBsum: 2CQ0 2MJC 5K0Y
  • DIP: 31115
  • STRING: ENSP00000253108
• Other Databases: GeneCards:  EIF3G  Malacards:  EIF3G

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0075525	viral translational termination-reinitiation	IDA	biological process
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0003723	RNA binding	IDA	molecular function
GO:0003723	RNA binding	IDA	molecular function
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0002183	cytoplasmic translational initiation	IEA	biological process
GO:0033290	eukaryotic 48S preinitiation complex	IEA	cellular component
GO:0016282	eukaryotic 43S preinitiation complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0001732	formation of cytoplasmic translation initiation complex	IEA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0006413	translational initiation	IDA	biological process
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005634	nucleus	IDA	NOT|cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq