• Gene id: 8665

Gene Summary

• Gene Symbol: EIF3F   Gene   UCSC   Ensembl
• Aliases: EIF3S5, MRT67, eIF3-p47
• Gene name: eukaryotic translation initiation factor 3 subunit F
• Alternate names: eukaryotic translation initiation factor 3 subunit F, deubiquitinating enzyme eIF3f, eIF-3-epsilon, eIF3-epsilon, eukaryotic translation initiation factor 3, subunit 5 (epsilon, 47kD), eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa,
• Gene location: 11p15.4 (7987336: 8001851)     Exons: 8     NC_000011.10
• OMIM: 603914

Protein Summary

• Protein general information: O00303  
  • Name: Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF 3 epsilon) (eIF3 p47)
  • Length: 357  
  • Mass: 37564
• Sequence:

  MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPGQTPASAQAPAQTPAP
  ALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDM
  EFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPG
  RTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSA
  DNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL

• Structural information:
  • Protein Domains: (92..22-)
    (/note="MPN-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01182"-)
  • Interpro: IPR027531  IPR000555  IPR037518  IPR024969  
  • Prosite: PS50249
  • CDD: cd08064
  • PDB: 3J8B 3J8C
  • PDBsum: 3J8B 3J8C
  • DIP: 35580
  • STRING: ENSP00000431800
• Other Databases: GeneCards:  EIF3F  Malacards:  EIF3F

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IDA	biological process
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0031369	translation initiation factor binding	IEA	molecular function
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0031369	translation initiation factor binding	IBA	molecular function
GO:0003743	translation initiation factor activity	IBA	contributes to
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	IBA	cellular component
GO:0006413	translational initiation	IBA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0006413	translational initiation	IEA	biological process
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	molecular function
GO:0101005	ubiquitinyl hydrolase activity	IDA	molecular function
GO:0016579	protein deubiquitination	IDA	biological process
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	IEA	cellular component
GO:0016579	protein deubiquitination	IEA	biological process
GO:0006413	translational initiation	IEA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0031369	translation initiation factor binding	IEA	molecular function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	IEA	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0075522	IRES-dependent viral translational initiation	IDA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	TAS	molecular function
GO:0002183	cytoplasmic translational initiation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0016282	eukaryotic 43S preinitiation complex	IEA	cellular component
GO:0033290	eukaryotic 48S preinitiation complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0001732	formation of cytoplasmic translation initiation complex	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881