• Gene id: 8663

Gene Summary

• Gene Symbol: EIF3C   Gene   UCSC   Ensembl
• Aliases: EIF3CL, EIF3S8, eIF3-p110
• Gene name: eukaryotic translation initiation factor 3 subunit C
• Alternate names: eukaryotic translation initiation factor 3 subunit C, cell migration-inducing protein 17, eIF3 p110, eukaryotic translation initiation factor 3 subunit 8, eukaryotic translation initiation factor 3, subunit 8 (110kD), eukaryotic translation initiation factor 3,
• Gene location: 16p11.2 (28688557: 28735729)     Exons: 29     NC_000016.10
• OMIM: 603916

Protein Summary

• Protein general information: Q99613  
  • Name: Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)
  • Length: 913  
  • Mass: 105344
• Sequence:

  MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRD
  VTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNR
  DFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDS
  EDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGE
  WERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIK
  FNIIASLYDYNPNLATYMKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVER
  MDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTP
  PEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQH
  ADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHL
  HINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWK
  TCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKM
  IINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMR
  RGGYRQQQSQTAY

• Structural information:
  • Protein Domains: (673..84-)
    (/note="PCI-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01185"-)
  • Interpro: IPR027516  IPR008905  IPR000717  IPR036388  IPR036390  
  • Prosite: PS50250
  • PDB: 3J8B 3J8C
  • PDBsum: 3J8B 3J8C
  • DIP: 32865
  • STRING: ENSP00000332604
• Other Databases: GeneCards:  EIF3C  Malacards:  EIF3C

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular function
GO:0045727	positive regulation of translation	IPI	biological process
GO:1902416	positive regulation of mRNA binding	IPI	biological process
GO:0031369	translation initiation factor binding	IBA	molecular function
GO:0003743	translation initiation factor activity	IBA	contributes to
GO:0005852	eukaryotic translation initiation factor 3 complex	IBA	cellular component
GO:0006413	translational initiation	IBA	biological process
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0031369	translation initiation factor binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0006412	translation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0043022	ribosome binding	IDA	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0033290	eukaryotic 48S preinitiation complex	IEA	cellular component
GO:0002183	cytoplasmic translational initiation	IEA	biological process
GO:0016282	eukaryotic 43S preinitiation complex	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0001732	formation of cytoplasmic translation initiation complex	IEA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IDA	biological process
GO:0006413	translational initiation	IC	biological process
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003723	RNA binding	HDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Cryptorchidism	MIK: 21412036
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21412036	Cryptorchidism			23 (4 controls, 19 cases)	Male infertility	GSE25518 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R