• Gene id: 8662

Gene Summary

• Gene Symbol: EIF3B   Gene   UCSC   Ensembl
• Aliases: EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1
• Gene name: eukaryotic translation initiation factor 3 subunit B
• Alternate names: eukaryotic translation initiation factor 3 subunit B, eukaryotic translation initiation factor 3 subunit 9, eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD), eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa, protein synthesi,
• Gene location: 7p22.3 (35299274: 35347993)     Exons: 17     NC_000022.11
• OMIM: 603917

Protein Summary

• Protein general information: P55884  
  • Name: Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF 3 eta) (eIF3 p110) (eIF3 p116)
  • Length: 814  
  • Mass: 92482
• Sequence:

  MQDAENVAVPEAAEERAEPGQQQPAAEPPPAEGLLRPAGPGAPEAAGTEASSEEVGIAEAGPESEVRTEPAAEAE
  AASGPSESPSPPAAEELPGSHAEPPVPAQGEAPGEQARDERSDSRAQAVSEDAGGNEGRAAEAEPRALENGDADE
  PSFSDPEDFVDDVSEEELLGDVLKDRPQEADGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKITNDFYPEE
  DGKTKGYIFLEYASPAHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEA
  ECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALWGGEKFKQIQRFSHQG
  VQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYE
  TPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDY
  LCVKVDRTPKGTQGVVTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKNNGKI
  ELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWDPTGRYVVTSVSWWSH
  KVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQEQIKQIKKDLKKYSKIFEQKDRLSQSKASKELVERR
  RTMMEDFRKYRKMAQELYMEQKNERLELRGGVDTDELDSNVDDWEEETIEFFVTEEIIPLGNQE

• Structural information:
  • Protein Domains: (185..26-)
    (/note="RRM-)
    (/evidence="ECO:0000255|HAMAP-Rule:MF_03001"-)
  • Interpro: IPR011400  IPR034363  IPR012677  IPR035979  IPR000504   IPR013979  IPR015943  
  • Prosite: PS50102
  • CDD: cd12278
  • PDB: 2KRB 2NLW 5K1H
  • PDBsum: 2KRB 2NLW 5K1H
  • DIP: 31113
  • STRING: ENSP00000354125
• Other Databases: GeneCards:  EIF3B  Malacards:  EIF3B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003743	translation initiation factor activity	IBA	contributes to
GO:0005852	eukaryotic translation initiation factor 3 complex	IBA	cellular component
GO:0006413	translational initiation	IBA	biological process
GO:0075522	IRES-dependent viral translational initiation	IDA	biological process
GO:0075525	viral translational termination-reinitiation	IDA	biological process
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0003723	RNA binding	IDA	molecular function
GO:0003723	RNA binding	IDA	molecular function
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0031369	translation initiation factor binding	IEA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	IEA	cellular component
GO:0045202	synapse	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0002183	cytoplasmic translational initiation	IEA	biological process
GO:0033290	eukaryotic 48S preinitiation complex	IEA	cellular component
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0016282	eukaryotic 43S preinitiation complex	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0001732	formation of cytoplasmic translation initiation complex	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IEA	cellular component
GO:0006413	translational initiation	IDA	biological process
GO:0006413	translational initiation	IDA	biological process
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0006446	regulation of translational initiation	IDA	biological process
GO:0003743	translation initiation factor activity	IDA	molecular function
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0003743	translation initiation factor activity	IC	contributes to
GO:0006413	translational initiation	IC	biological process
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0005852	eukaryotic translation initiation factor 3 complex	IDA	cellular component
GO:0003743	translation initiation factor activity	IDA	contributes to
GO:0070062	extracellular exosome	HDA	cellular component
GO:0060090	molecular adaptor activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray