• Gene id: 86614

Gene Summary

• Gene Symbol: HSFY1   Gene   UCSC   Ensembl
• Aliases: HSF2L, HSFY
• Gene name: heat shock transcription factor, Y-linked 1
• Alternate names: heat shock transcription factor, Y-linked, heat shock transcription factor 2-like protein,
• Gene location: Yq11.222 (18529677: 18588962)     Exons: 9     NC_000024.10
• Gene summary(Entrez): This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile ma
• OMIM: 400029

Protein Summary

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 26162009
Maturation arrest	MIK: 22820855
Male factor infertility	MIK: 15044259
Oligozoospermia	MIK: 15044259
Spermatogenesis defects	MIK: 14985478
Sertoli cell only syndrome (SCOS)	MIK: 16952509
Varicocele	MIK: 20096881
Obstructive azoospermia	MIK: 22820855
Azoospermia	MIK: 22158087
Oligozoospermia	MIK: 20096881
Azoospermia	MIK: 1573489
Oligozoospermia	MIK: 15044259
Male infertility	MIK: 15044259
Obstructive azoospermia	MIK: 22820855
Sertoli cell-only syndrome	MIK: 16952509
Non- obstructive azoospermia	MIK: 26162009
Varicocele	MIK: 20096881
Spermatogenesis defects	MIK: 14985478

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R
20096881	Oligozoospermia, varicocele			185 (117 consecutive patients with varicocele, 68 controls without varicocele)	Male infertility	HSP90  HSPA4 HSF1 HSF2 and HSFY
14985478	Spermatogenesis				Male infertility
15044259	Azoospermia, oligospermia, Male infertility				Male infertility
26162009	Non- obstructive azoospermia, maturation arrest			80 (12 men with preserved spermatogenesis, 68 men with nonobstructive azoospermia (NOA) (40 Sertoli-cell-only syndrome (SCOS) and 28 premiotic maturation arrest (MA)))	Male infertility	USP9Y DDX3Y XKRY HSFY1 CYORF15A CYORF15B KDM5D EIF1AY RPS4Y2 RBMY1A1 PRY BPY2 DAZ1 and CDY1
22820855	Maturation arrest, obstructive azoospermia		America n	132 men with Y-chromosome microdeletions	Male infertility	CDY2 HSFY
22158087	Oligozoospermia, azoospermia	768 kb deletion resulting in loss of the entire P4 palindrome		2365 (1186 men from infertile couples for Y chromosome deletions, and identified three unrelated oligozoospermic men and one azoospermic man, 1179 control men)	Male infertility	CDY2 XKRY  HSFY1 HSFY2 CYORF15A CYORF15B KDM5D EIF1AY RPS4Y2 RBMY
20096881	Oligozoospermia, varicocele			185 (117 consecutive patients with varicocele, 68 controls without varicocele)	Male infertility	HSP90 HSPA4 HSF1 HSF2 and HSFY
16952509	Maturation arrest, Sertoli cell-only syndrome			17 (8 normal aspermatogenesis, 5 maturation arrest, 4 Sertoli cell- only syndrome)	Male infertility
1573489	Azoospermia				Male infertility	EIF1AY RPS4Y2 RBMY1 HSFY
15044259	Azoospermia, Oligozoospermia			2 azoospermic males	Male infertility	HSFY LW-1 HSFYL
15734897	Idiopathic azoospermia	Y chromosome microdeletion			Male infertility	HSFY