• Gene id: 8574

Gene Summary

• Gene Symbol: AKR7A2   Gene   UCSC   Ensembl
• Aliases: AFAR, AFAR1, AFB1-AR1, AKR7
• Gene name: aldo-keto reductase family 7 member A2
• Alternate names: aflatoxin B1 aldehyde reductase member 2, AFB1 aldehyde reductase 1, AFB1-AR 1, HEL-S-166mP, SSA reductase, aflatoxin aldehyde reductase, aflatoxin beta1 aldehyde reductase, aldoketoreductase 7, epididymis secretory sperm binding protein Li 166mP, succinic semiald,
• Gene location: 1p36.13 (73458579: 73275209)     Exons: 14     NC_000014.9
• Gene summary(Entrez): The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chr
• OMIM: 603418

Protein Summary

• Protein general information: O43488  
  • Name: Aflatoxin B1 aldehyde reductase member 2 (EC 1.1.1.n11) (AFB1 aldehyde reductase 1) (AFB1 AR 1) (Aldoketoreductase 7) (Succinic semialdehyde reductase) (SSA reductase)
  • Length: 359  
  • Mass: 39589
  • Tissue specificity: Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. De
• Sequence:

  MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAF
  MYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVE
  ETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAY
  NPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMY
  HHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR

• Structural information:
  • Interpro: IPR023210  IPR036812  
  • CDD: cd06660
  • PDB: 2BP1
  • PDBsum: 2BP1
  • STRING: ENSP00000235835
• Other Databases: GeneCards:  AKR7A2  Malacards:  AKR7A2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	TAS	molecular function
GO:0005975	carbohydrate metabolic process	TAS	biological process
GO:0006081	cellular aldehyde metabolic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0006805	xenobiotic metabolic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0022900	electron transport chain	IEA	biological process
GO:0019119	phenanthrene-9,10-epoxide hydrolase activity	IDA	molecular function
GO:0044597	daunorubicin metabolic process	IMP	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0044598	doxorubicin metabolic process	IMP	biological process
GO:0009055	electron transfer activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa00980	Metabolism of xenobiotics by cytochrome P450

Diseases

Associated diseases	References
Alzheimer's disease	PMID:11597610
pancreatic ductal adenocarcinoma	PMID:19077459
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)