• Gene id: 85406

Gene Summary

• Gene Symbol: DNAJC14   Gene   UCSC   Ensembl
• Aliases: DNAJ, DRIP78, HDJ3, LIP6
• Gene name: DnaJ heat shock protein family (Hsp40) member C14
• Alternate names: dnaJ homolog subfamily C member 14, DnaJ (Hsp40) homolog, subfamily C, member 14, LYST-interacting protein LIP6, dnaJ protein homolog 3, dopamine receptor interacting protein, dopamine receptor-interacting protein of 78 kDa, hDj-3, human DnaJ protein 3,
• Gene location: 12q13.2 (55829635: 55820959)     Exons: 7     NC_000012.12
• OMIM: 136430

Protein Summary

• Protein general information: Q6Y2X3  
  • Name: DnaJ homolog subfamily C member 14 (DnaJ protein homolog 3) (Dopamine receptor interacting protein of 78 kDa) (DRIP78) (Human DnaJ protein 3) (hDj 3)
  • Length: 702  
  • Mass: 78569
  • Tissue specificity: Highly expressed in pancreas and selectively expressed in brain, lung, liver, skeletal muscle and kidney. {ECO
• Sequence:

  MAQKHPGERGLYGAHHSGGASLRTLGPSVDPEIPSFSGLRDSAGTAPNGTRCLTEHSGPKHTQHPNPAHWLDPSH
  GPPGGPGPPRDAEDPDQSETSSEEESGVDQELSKENETGNQKDGNSFLSIPSACNCQGTPGIPEGPYSEGGNGSS
  SNFCHHCTSPALGEDELEEEYDDEESLKFPSDFSRVSSGKKPPSRRQRHRFPTKEDTREGGRRDPRSPGRHRLGR
  KRSQADKRKGLGLWGAEELCQLGQAGFWWLIELLVLVGEYVETCGHLIYACRQLKSSDLDLFRVWMGVWTGRLGG
  WAQVMFQFLSQGFYCGVGLFTRFLKLLGALLLLALALFLGFLQLGWRFLVGLGDRLGWRDKATWLFSWLDSPALQ
  RCLTLLRDSRPWQRLVRIVQWGWLELPWVKQNINRQGNAPVASGRYCQPEEEVARLLTMAGVPEDELNPFHVLGV
  EATASDVELKKAYRQLAVMVHPDKNHHPRAEEAFKVLRAAWDIVSNAEKRKEYEMKRMAENELSRSVNEFLSKLQ
  DDLKEAMNTMMCSRCQGKHRRFEMDREPKSARYCAECNRLHPAEEGDFWAESSMLGLKITYFALMDGKVYDITEW
  AGCQRVGISPDTHRVPYHISFGSRIPGTRGRQRATPDAPPADLQDFLSRIFQVPPGQMPNGNFFAAPQPAPGAAA
  ASKPNSTVPKGEAKPKRRKKVRRPFQR

• Structural information:
  • Protein Domains: (443..50-)
    (/note="J-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00286"-)
  • Interpro: IPR001623  IPR036869  IPR032843  
  • Prosite: PS50076
  • CDD: cd06257
  • STRING: ENSP00000350223
• Other Databases: GeneCards:  DNAJC14  Malacards:  DNAJC14

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R