• Gene id: 8527

Gene Summary

• Gene Symbol: DGKD   Gene   UCSC   Ensembl
• Aliases: DGK-delta, DGKdelta, dgkd-2
• Gene name: diacylglycerol kinase delta
• Alternate names: diacylglycerol kinase delta, DAG kinase delta, diacylglycerol kinase, delta 130kDa, diglyceride kinase delta,
• Gene location: 2q37.1 (233354493: 233472097)     Exons: 40     NC_000002.12
• Gene summary(Entrez): This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by
• OMIM: 608179

Protein Summary

• Protein general information: Q16760  
  • Name: Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK delta)
  • Length: 1214  
  • Mass: 134525
  • Tissue specificity: Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells. {ECO
• Sequence:

  MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYF
  KLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHF
  EPTQYSMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDI
  IEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTA
  LNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRIL
  VCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA
  YEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKT
  TESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARP
  QIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVCPPLSHSESFGVPKGR
  SQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNS
  EPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLEC
  DGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCR
  TVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSE
  EEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRS
  ETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKK
  EKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILC
  GIKELSRSAPAVEA

• Structural information:
  • Protein Domains: (53..14-)
    (/note="PH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145-)
    (317..45-)
    (/note="DAGKc-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00783-)
    (1145..120-)
    (/note="SAM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00184"-)
  • Interpro: IPR017438  IPR037607  IPR037606  IPR000756  IPR001206   IPR016064  IPR002219  IPR011993  IPR001849  IPR001660  IPR013761  
  • Prosite: PS50146 PS50003 PS50105 PS00479 PS50081
  • CDD: cd00029 cd09575
  • PDB: 1R79 3BQ7
  • PDBsum: 1R79 3BQ7
  • DIP: 29646
  • STRING: ENSP00000264057
• Other Databases: GeneCards:  DGKD  Malacards:  DGKD

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004143	diacylglycerol kinase activity	IBA	molecular function
GO:0035556	intracellular signal transduction	IBA	biological process
GO:0046339	diacylglycerol metabolic process	IBA	biological process
GO:0046486	glycerolipid metabolic process	IBA	biological process
GO:0046834	lipid phosphorylation	IBA	biological process
GO:0006654	phosphatidic acid biosynthetic process	IDA	biological process
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0005905	clathrin-coated pit	IDA	cellular component
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0006654	phosphatidic acid biosynthetic process	IDA	biological process
GO:0046339	diacylglycerol metabolic process	IDA	biological process
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0046339	diacylglycerol metabolic process	IDA	biological process
GO:0090038	negative regulation of protein kinase C signaling	ISS	biological process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:2000370	positive regulation of clathrin-dependent endocytosis	IMP	biological process
GO:0003951	NAD+ kinase activity	IEA	molecular function
GO:0004143	diacylglycerol kinase activity	IEA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0042803	protein homodimerization activity	IEA	molecular function
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0046982	protein heterodimerization activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0006897	endocytosis	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0004143	diacylglycerol kinase activity	IEA	molecular function
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0046982	protein heterodimerization activity	IDA	molecular function
GO:0046339	diacylglycerol metabolic process	IC	biological process
GO:0030168	platelet activation	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	TAS	cellular component
GO:0046834	lipid phosphorylation	TAS	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0010033	response to organic substance	IDA	biological process
GO:0005886	plasma membrane	IDA	cellular component
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	NAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0046339	diacylglycerol metabolic process	NAS	biological process
GO:0007275	multicellular organism development	NAS	biological process
GO:0004143	diacylglycerol kinase activity	TAS	molecular function
GO:0004143	diacylglycerol kinase activity	TAS	molecular function
GO:0019992	diacylglycerol binding	NAS	molecular function
GO:0019932	second-messenger-mediated signaling	NAS	biological process
GO:0007173	epidermal growth factor receptor signaling pathway	NAS	biological process
GO:0019900	kinase binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04072	Phospholipase D signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa00564	Glycerophospholipid metabolism
hsa05231	Choline metabolism in cancer
hsa00561	Glycerolipid metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray