• Gene id: 8525

Gene Summary

• Gene Symbol: DGKZ   Gene   UCSC   Ensembl
• Aliases: DAGK5, DAGK6, DGK-ZETA, hDGKzeta
• Gene name: diacylglycerol kinase zeta
• Alternate names: diacylglycerol kinase zeta, DAG kinase zeta, diacylglycerol kinase, zeta 104kDa, diglyceride kinase zeta,
• Gene location: 11p11.2 (46332904: 46380553)     Exons: 10     NC_000011.10
• Gene summary(Entrez): The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs
• OMIM: 601441

Protein Summary

• Protein general information: Q13574  
  • Name: Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK zeta)
  • Length: 1117  
  • Mass: 124128
  • Tissue specificity: Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. Isoform 1 is predominantly expressed in muscle.
• Sequence:

  METFFRRHFRGKVPGPGEGQQRPSSVGLPTGKARRRSPAGQASSSLAQRRRSSAQLQGCLLSCGVRAQGSSRRRS
  STVPPSCNPRFIVDKVLTPQPTTVGAQLLGAPLLLTGLVGMNEEEGVQEDVVAEASSAIQPGTKTPGPPPPRGAQ
  PLLPLPRYLRRASSHLLPADAVYDHALWGLHGYYRRLSQRRPSGQHPGPGGRRASGTTAGTMLPTRVRPLSRRRQ
  VALRRKAAGPQAWSALLAKAITKSGLQHLAPPPPTPGAPCSESERQIRSTVDWSESATYGEHIWFETNVSGDFCY
  VGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRH
  CGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKK
  KRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPKEA
  LEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEG
  NVVQLDRWDLHAEPNPEAGPEDRDEGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAG
  TAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEV
  IGFTMTSLAALQVGGHGERLTQCREVVLTTSKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSAAPLHSD
  QQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKL
  SPKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPTSPCSPTPRSLQGDA
  APPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDEQSRTLLHHAVSTGSKDVVRYLLDHAPPEILDAVEENGETC
  LHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV

• Structural information:
  • Protein Domains: (480..61-)
    (/note="DAGKc-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00783"-)
  • Interpro: IPR002110  IPR020683  IPR036770  IPR017438  IPR037607   IPR000756  IPR001206  IPR016064  IPR002219  
  • Prosite: PS50297 PS50088 PS50146
  • CDD: cd00029
  • PDB: 5ELQ
  • PDBsum: 5ELQ
  • STRING: ENSP00000412178
• Other Databases: GeneCards:  DGKZ  Malacards:  DGKZ

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004143	diacylglycerol kinase activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0035556	intracellular signal transduction	IBA	biological process
GO:0046339	diacylglycerol metabolic process	IBA	biological process
GO:0046486	glycerolipid metabolic process	IBA	biological process
GO:0046834	lipid phosphorylation	IBA	biological process
GO:0051966	regulation of synaptic transmission, glutamatergic	IBA	biological process
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0006654	phosphatidic acid biosynthetic process	IDA	biological process
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0046339	diacylglycerol metabolic process	IDA	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0006654	phosphatidic acid biosynthetic process	IDA	biological process
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0046339	diacylglycerol metabolic process	IDA	biological process
GO:0006654	phosphatidic acid biosynthetic process	TAS	biological process
GO:0006654	phosphatidic acid biosynthetic process	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0090216	positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0050860	negative regulation of T cell receptor signaling pathway	ISS	biological process
GO:0003951	NAD+ kinase activity	IEA	molecular function
GO:0004143	diacylglycerol kinase activity	IEA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0035556	intracellular signal transduction	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005524	ATP binding	TAS	molecular function
GO:0004143	diacylglycerol kinase activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0030168	platelet activation	TAS	biological process
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0004143	diacylglycerol kinase activity	IEA	molecular function
GO:0014069	postsynaptic density	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0016301	kinase activity	IDA	molecular function
GO:0004143	diacylglycerol kinase activity	IDA	molecular function
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0046339	diacylglycerol metabolic process	IDA	biological process
GO:0046486	glycerolipid metabolic process	IDA	biological process
GO:0046834	lipid phosphorylation	IDA	biological process
GO:0005737	cytoplasm	TAS	cellular component
GO:0005829	cytosol	IEA	cellular component
GO:0030027	lamellipodium	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016607	nuclear speck	IDA	cellular component
GO:0046486	glycerolipid metabolic process	IEA	biological process
GO:0030027	lamellipodium	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0016477	cell migration	NAS	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04072	Phospholipase D signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa00564	Glycerophospholipid metabolism
hsa05231	Choline metabolism in cancer
hsa00561	Glycerolipid metabolism

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq