• Gene id: 84817

Gene Summary

• Gene Symbol: TXNDC17   Gene   UCSC   Ensembl
• Aliases: TRP14, TXNL5
• Gene name: thioredoxin domain containing 17
• Alternate names: thioredoxin domain-containing protein 17, 14 kDa thioredoxin-related protein, protein 42-9-9, testicular tissue protein Li 214, thioredoxin (Trx)-related protein, 14 kDa, thioredoxin-like 5, thioredoxin-like protein 5,
• Gene location: 17p13.1 (6641059: 6644540)     Exons: 4     NC_000017.11
• OMIM: 610609

Protein Summary

• Protein general information: Q9BRA2  
  • Name: Thioredoxin domain containing protein 17 (14 kDa thioredoxin related protein) (TRP14) (Protein 42 9 9) (Thioredoxin like protein 5)
  • Length: 123  
  • Mass: 13941
  • Tissue specificity: Ubiquitously expressed in cell lines. {ECO
• Sequence:

  MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHISEGCVFIYCQVGEKP
  YWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLFSED

• Structural information:
  • Protein Domains: (41..12-)
    (/note="Thioredoxin-)
    (/evidence="ECO:0000255"-)
  • Interpro: IPR010357  IPR036249  
  • PDB: 1WOU
  • PDBsum: 1WOU
  • STRING: ENSP00000250101
• Other Databases: GeneCards:  TXNDC17  Malacards:  TXNDC17

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005829	cytosol	IDA	cellular component
GO:0047134	protein-disulfide reductase activity	IDA	molecular function
GO:0047134	protein-disulfide reductase activity	IDA	molecular function
GO:0004601	peroxidase activity	IDA	molecular function
GO:0047134	protein-disulfide reductase activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0033209	tumor necrosis factor-mediated signaling pathway	IMP	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0047134	protein-disulfide reductase activity	IBA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq