• Gene id: 84661

Gene Summary

• Gene Symbol: DPY30   Gene   UCSC   Ensembl
• Aliases: Cps25, HDPY-30, Saf19
• Gene name: dpy-30 histone methyltransferase complex regulatory subunit
• Alternate names: protein dpy-30 homolog, dpy-30 homolog, dpy-30-like protein, dpy-30L,
• Gene location: 2p22.3 (32039839: 32011648)     Exons: 10     NC_000002.12
• Gene summary(Entrez): This gene encodes an integral core subunit of the SET1/MLL family of H3K4 methyltransferases. The encoded protein directly controls cell cycle regulators and plays an important role in the proliferation and differentiation of human hematopoietic progenito
• OMIM: 612032

Protein Summary

• Protein general information: Q9C005  
  • Name: Protein dpy 30 homolog (Dpy 30 like protein) (Dpy 30L)
  • Length: 99  
  • Mass: 11250
• Sequence:

  MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKE
  RPPNPIEFLASYLLKNKAQFEDRN

• Structural information:
  • Interpro: IPR007858  IPR037856  
  • PDB: 3G36 4RIQ 4RT4 4RTA 6E2H 6PWV
  • PDBsum: 3G36 4RIQ 4RT4 4RTA 6E2H 6PWV
  • DIP: 34476
  • STRING: ENSP00000345837
• Other Databases: GeneCards:  DPY30  Malacards:  DPY30

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051568	histone H3-K4 methylation	IBA	biological process
GO:0048188	Set1C/COMPASS complex	IBA	cellular component
GO:0044666	MLL3/4 complex	IDA	cellular component
GO:0035097	histone methyltransferase complex	IDA	cellular component
GO:0005802	trans-Golgi network	IDA	cellular component
GO:0051568	histone H3-K4 methylation	IDA	biological process
GO:0048188	Set1C/COMPASS complex	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0042803	protein homodimerization activity	IPI	molecular function
GO:0016197	endosomal transport	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0044666	MLL3/4 complex	IEA	cellular component
GO:0048188	Set1C/COMPASS complex	IEA	cellular component
GO:0006325	chromatin organization	IEA	biological process
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0035097	histone methyltransferase complex	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0045652	regulation of megakaryocyte differentiation	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)