• Gene id: 8463

Gene Summary

• Gene Symbol: TEAD2   Gene   UCSC   Ensembl
• Aliases: ETF, TEAD-2, TEF-4, TEF4
• Gene name: TEA domain transcription factor 2
• Alternate names: transcriptional enhancer factor TEF-4, TEA domain family member 2,
• Gene location: 19q13.33 (49362451: 49340594)     Exons: 17     NC_000019.10
• OMIM: 601729

Protein Summary

• Protein general information: Q15562  
  • Name: Transcriptional enhancer factor TEF 4 (TEA domain family member 2) (TEAD 2)
  • Length: 447  
  • Mass: 49243
• Sequence:

  MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGK
  MYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKL
  GPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGT
  ARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLV
  KFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLL
  RSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD

• Structural information:
  • Interpro: IPR000818  IPR038096  IPR016361  IPR041086  
  • Prosite: PS00554 PS51088
  • PDB: 3L15 5DQ8 5DQE 5EMV 5HGU 6E5G
  • PDBsum: 3L15 5DQ8 5DQE 5EMV 5HGU 6E5G
  • DIP: 59318
  • STRING: ENSP00000472109
• Other Databases: GeneCards:  TEAD2  Malacards:  TEAD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000790	nuclear chromatin	ISA	cellular component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	molecular function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0005667	transcription regulator complex	IBA	cellular component
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	biological process
GO:0048568	embryonic organ development	IBA	biological process
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	molecular function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	molecular function
GO:0035329	hippo signaling	IBA	biological process
GO:0035329	hippo signaling	IDA	biological process
GO:0035329	hippo signaling	IDA	biological process
GO:0003700	DNA-binding transcription factor activity	IDA	molecular function
GO:0003700	DNA-binding transcription factor activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003700	DNA-binding transcription factor activity	IEA	molecular function
GO:0035329	hippo signaling	IEA	biological process
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0060548	negative regulation of cell death	IEA	biological process
GO:0030903	notochord development	IEA	biological process
GO:0001570	vasculogenesis	IEA	biological process
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA	molecular function
GO:2000736	regulation of stem cell differentiation	IEA	biological process
GO:0071300	cellular response to retinoic acid	IEA	biological process
GO:0048368	lateral mesoderm development	IEA	biological process
GO:0048339	paraxial mesoderm development	IEA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	biological process
GO:0005667	transcription regulator complex	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0003143	embryonic heart tube morphogenesis	IEA	biological process
GO:0001843	neural tube closure	IEA	biological process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0001223	transcription coactivator binding	IPI	molecular function
GO:0003700	DNA-binding transcription factor activity	IMP	molecular function
GO:0097718	disordered domain specific binding	IMP	molecular function
GO:0065003	protein-containing complex assembly	IMP	biological process
GO:0045893	positive regulation of transcription, DNA-templated	IMP	biological process
GO:0071149	TEAD-2-YAP complex	IDA	cellular component
GO:0006355	regulation of transcription, DNA-templated	NAS	biological process
GO:0003700	DNA-binding transcription factor activity	NAS	molecular function
GO:0005634	nucleus	NAS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04390	Hippo signaling pathway
hsa04392	Hippo signaling pathway - multiple species

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R