• Gene id: 84524

Gene Summary

• Gene Symbol: ZC3H8   Gene   UCSC   Ensembl
• Aliases: Fliz1, ZC3HDC8
• Gene name: zinc finger CCCH-type containing 8
• Alternate names: zinc finger CCCH domain-containing protein 8, zinc finger CCCH-type domain containing 8,
• Gene location: 2q14.1 (66347628: 66345373)     Exons: 2     NC_000011.10

Protein Summary

• Protein general information: Q8N5P1  
  • Name: Zinc finger CCCH domain containing protein 8
  • Length: 291  
  • Mass: 33576
• Sequence:

  MDFENLFSKPPNPALGKTATDSDERIDDEIDTEVEETQEEKIKLECEQIPKKFRHSAISPKSSLHRKSRSKDYDV
  YSDNDICSQESEDNFAKELQQYIQAREMANAAQPEESTKKEGVKDTPQAAKQKNKNLKAGHKNGKQKKMKRKWPG
  PGNKGSNALLRNSGSQEEDGKPKEKQQHLSQAFINQHTVERKGKQICKYFLERKCIKGDQCKFDHDAEIEKKKEM
  CKFYVQGYCTRGENCLYLHNEYPCKFYHTGTKCYQGEYCKFSHAPLTPETQELLAKVLDTEKKSCK

• Structural information:
  • Interpro: IPR000571  IPR036855  
  • Prosite: PS50103
  • STRING: ENSP00000386488
• Other Databases: GeneCards:  ZC3H8  Malacards:  ZC3H8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000790	nuclear chromatin	ISA	cellular component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA	molecular function
GO:0003700	DNA-binding transcription factor activity	IBA	molecular function
GO:0045892	negative regulation of transcription, DNA-templated	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0035327	transcriptionally active chromatin	IDA	cellular component
GO:0035363	histone locus body	IDA	cellular component
GO:0008023	transcription elongation factor complex	IDA	cellular component
GO:0015030	Cajal body	IDA	cellular component
GO:0043565	sequence-specific DNA binding	ISS	molecular function
GO:0042796	snRNA transcription by RNA polymerase III	IMP	biological process
GO:0045945	positive regulation of transcription by RNA polymerase III	IMP	biological process
GO:0042795	snRNA transcription by RNA polymerase II	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0006915	apoptotic process	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0042795	snRNA transcription by RNA polymerase II	TAS	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IEA	biological process
GO:0043565	sequence-specific DNA binding	IEA	molecular function
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component
GO:0046677	response to antibiotic	IDA	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IDA	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0005634	nucleus	ISS	cellular component
GO:0045892	negative regulation of transcription, DNA-templated	ISS	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0070245	positive regulation of thymocyte apoptotic process	IMP	biological process
GO:0043029	T cell homeostasis	IMP	biological process
GO:0033085	negative regulation of T cell differentiation in thymus	IMP	biological process
GO:0003700	DNA-binding transcription factor activity	IMP	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)