• Gene id: 8451

Gene Summary

• Gene Symbol: CUL4A   Gene   UCSC   Ensembl
• Gene name: cullin 4A
• Alternate names: cullin-4A, CUL-4A,
• Gene location: 13q34 (113208192: 113267107)     Exons: 25     NC_000013.11
• Gene summary(Entrez): CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]
• OMIM: 603137

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category

KEGG pathways

Pathway id	Pathway name
hsa05170	Human immunodeficiency virus 1 infection
hsa04120	Ubiquitin mediated proteolysis
hsa05170	Human immunodeficiency virus 1 infection
hsa03420	Nucleotide excision repair

Diseases

Associated diseases	References
Essential for spermatogenesis	MIK: 21291880
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 21412036
Spermatogenic defects	MIK: 21291880
Male infertility	MIK: 21291880
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21291880	Essential role in spermatogenesis, Male infertility				Male infertility
21412036	Cryptorchidism			23 (4 controls, 19 cases)	Male infertility	GSE25518 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray