• Gene id: 8428

Gene Summary

• Gene Symbol: STK24   Gene   UCSC   Ensembl
• Aliases: HEL-S-95, MST3, MST3B, STE20, STK3
• Gene name: serine/threonine kinase 24
• Alternate names: serine/threonine-protein kinase 24, STE20-like kinase 3, STE20-like kinase MST3, epididymis secretory protein Li 95, mammalian STE20-like protein kinase 3, serine/threonine kinase 24 (STE20 homolog, yeast), sterile 20-like kinase 3,
• Gene location: 13q32.2 (98577150: 98450198)     Exons: 14     NC_000013.11
• Gene summary(Entrez): This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and
• OMIM: 604984

Protein Summary

• Protein general information: Q9Y6E0  
  • Name: Serine/threonine protein kinase 24 (EC 2.7.11.1) (Mammalian STE20 like protein kinase 3) (MST 3) (STE20 like kinase MST3) [Cleaved into: Serine/threonine protein kinase 24 36 kDa subunit (Mammalian STE20 like protein kinase 3 N terminal) (MST3/N); Serine/
  • Length: 443  
  • Mass: 49308
  • Tissue specificity: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
• Sequence:

  MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDE
  IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE
  KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELA
  RGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI
  DRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQC
  LSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH

• Structural information:
  • Protein Domains: (36..28-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR000719  IPR017441  
  • Prosite: PS00107 PS50011
  • PDB: 3A7F 3A7G 3A7H 3A7I 3A7J 3CKW 3CKX 3ZHP 4O27 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ 4QNA 4QO9 4U8Z 4W8D 4W8E
  • PDBsum: 3A7F 3A7G 3A7H 3A7I 3A7J 3CKW 3CKX 3ZHP 4O27 4QML 4QMM 4QMN 4QMO 4QMP 4QMQ 4QMS 4QMT 4QMU 4QMV 4QMW 4QMX 4QMY 4QMZ 4QNA 4QO9 4U8Z 4W8D 4W8E
  • DIP: 40608
  • STRING: ENSP00000365730
• Other Databases: GeneCards:  STK24  Malacards:  STK24

Gene ontology

GO accession	Term name	Evidence code	Go category

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq