• Gene id: 84262

Gene Summary

• Gene Symbol: PSMG3   Gene   UCSC   Ensembl
• Aliases: C7orf48, PAC3
• Gene name: proteasome assembly chaperone 3
• Alternate names: proteasome assembly chaperone 3, PAC-3, hPAC3, proteasome (prosome, macropain) assembly chaperone 3, proteasome assembling chaperone 3,
• Gene location: 7p22.3 (1570489: 1567331)     Exons: 4     NC_000007.14
• OMIM: 617528

Protein Summary

• Protein general information: Q9BT73  
  • Name: Proteasome assembly chaperone 3 (PAC 3) (hPAC3)
  • Length: 122  
  • Mass: 13104
• Sequence:

  MEDTPLVISKQKTEVVCGVPTQVVCTAFSSHILVVVTQFGKMGTLVSLEPSSVASDVSKPVLTTKVLLGQDEPLI
  HVFAKNLVAFVSQEAGNRAVLLAVAVKDKSMEGLKALREVIRVCQVW

• Structural information:
  • Interpro: IPR018788  
  • PDB: 2Z5E 6JPT
  • PDBsum: 2Z5E 6JPT
  • STRING: ENSP00000288607
• Other Databases: GeneCards:  PSMG3  Malacards:  PSMG3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032991	protein-containing complex	IEA	cellular component
GO:0044877	protein-containing complex binding	IEA	molecular function
GO:0044877	protein-containing complex binding	IDA	molecular function
GO:0032991	protein-containing complex	ISS	cellular component
GO:0060090	molecular adaptor activity	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0051131	chaperone-mediated protein complex assembly	IMP	biological process
GO:0051131	chaperone-mediated protein complex assembly	IMP	biological process
GO:0060090	molecular adaptor activity	IMP	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881