• Gene id: 84191

Gene Summary

• Gene Symbol: CIAO2A   Gene   UCSC   Ensembl
• Aliases: CIA2A, FAM96A
• Gene name: cytosolic iron-sulfur assembly component 2A
• Alternate names: cytosolic iron-sulfur assembly component 2A, MIP18 family protein FAM96A, family with sequence similarity 96 member A,
• Gene location: 15q22.31 (64094007: 64072558)     Exons: 6     NC_000015.10
• OMIM: 618382

Protein Summary

• Protein general information: Q9H5X1  
  • Name: Cytosolic iron sulfur assembly component 2A (MIP18 family protein FAM96A)
  • Length: 160  
  • Mass: 18355
  • Tissue specificity: Substantially enriched in macrophages. {ECO
• Sequence:

  MQRVSGLLSWTLSRVLWLSGLSEPGAARQPRIMEEKALEVYDLIRTIRDPEKPNTLEELEVVSESCVEVQEINEE
  EYLVIIRFTPTVPHCSLATLIGLCLRVKLQRCLPFKHKLEIYISEGTHSTEEDINKQINDKERVAAAMENPNLRE
  IVEQCVLEPD

• Structural information:
  • Interpro: IPR034904  IPR039796  IPR002744  
  • PDB: 2M5H 3UX2 3UX3
  • PDBsum: 2M5H 3UX2 3UX3
  • STRING: ENSP00000300030
• Other Databases: GeneCards:  CIAO2A  Malacards:  CIAO2A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0097361	CIA complex	IDA	cellular component
GO:0097428	protein maturation by iron-sulfur cluster transfer	IMP	biological process
GO:0016226	iron-sulfur cluster assembly	IMP	biological process
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0007059	chromosome segregation	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray