• Gene id: 84182

Gene Summary

• Gene Symbol: MINDY4   Gene   UCSC   Ensembl
• Aliases: AQP-1, AQP1, C7orf67, CHIP28, FAM188B
• Gene name: MINDY lysine 48 deubiquitinase 4
• Alternate names: probable ubiquitin carboxyl-terminal hydrolase MINDY-4, Aquaporin-1, Aquaporin-CHIP, MINDY deubiquitinase 4, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, family with sequence similarity 188 member B, probable deubiqu,
• Gene location: 7p14.3 (30771416: 30892386)     Exons: 18     NC_000007.14

Protein Summary

• Protein general information: Q4G0A6  
  • Name: Probable ubiquitin carboxyl terminal hydrolase MINDY 4 (EC 3.4.19.12) (Probable deubiquitinating enzyme MINDY 4)
  • Length: 757  
  • Mass: 84372
• Sequence:

  MDSLFVEEVAASLVREFLSRKGLKKTCVTMDQERPRSDLSINNRNDLRKVLHLEFLYKENKAKENPLKTSLELIT
  RYFLDHFGNTANNFTQDTPIPALSVPKKNNKVPSRCSETTLVNIYDLSDEDAGWRTSLSETSKARHDNLDGDVLG
  NFVSSKRPPHKSKPMQTVPGETPVLTSAWEKIDKLHSEPSLDVKRMGENSRPKSGLIVRGMMSGPIASSPQDSFH
  RHYLRRSSPSSSSTQPQEESRKVPELFVCTQQDILASSNSSPSRTSLGQLSELTVERQKTTASSPPHLPSKRLPP
  WDRARPRDPSEDTPAVDGSTDTDRMPLKLYLPGGNSRMTQERLERAFKRQGSQPAPVRKNQLLPSDKVDGELGAL
  RLEDVEDELIREEVILSPVPSVLKLQTASKPIDLSVAKEIKTLLFGSSFCCFNEEWKLQSFSFSNTASLKYGIVQ
  NKGGPCGVLAAVQGCVLQKLLFEGDSKADCAQGLQPSDAHRTRCLVLALADIVWRAGGRERAVVALASRTQQFSP
  TGKYKADGVLETLTLHSLTCYEDLVTFLQQSIHQFEVGPYGCILLTLSAILSRSTELIRQDFDVPTSHLIGAHGY
  CTQELVNLLLTGKAVSNVFNDVVELDSGDGNITLLRGIAARSDIGFLSLFEHYNMCQVGCFLKTPRFPIWVVCSE
  SHFSILFSLQPGLLRDWRTERLFDLYYYDGLANQQEQIRLTIDTTQTISEDTDNDLVPPLELCIRTKWKGASVNW
  NGSDPIL

• Structural information:
  • Interpro: IPR025257  IPR039785  
  • STRING: ENSP00000265299
• Other Databases: GeneCards:  MINDY4  Malacards:  MINDY4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016807	cysteine-type carboxypeptidase activity	IBA	molecular function
GO:1990380	Lys48-specific deubiquitinase activity	IBA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	IEA	molecular function
GO:0071108	protein K48-linked deubiquitination	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq