• Gene id: 84064

Gene Summary

• Gene Symbol: HDHD2   Gene   UCSC   Ensembl
• Aliases: 3110052N05Rik, HEL-S-301
• Gene name: haloacid dehalogenase like hydrolase domain containing 2
• Alternate names: haloacid dehalogenase-like hydrolase domain-containing protein 2, epididymis secretory protein Li 301, epididymis secretory sperm binding protein,
• Gene location: 18q21.1 (48270080: 48287607)     Exons: 9     NC_000019.10

Protein Summary

• Protein general information: Q9H0R4  
  • Name: Haloacid dehalogenase like hydrolase domain containing protein 2
  • Length: 259  
  • Mass: 28536
• Sequence:

  MAACRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFDISEDEIFTS
  LTAARSLLERKQVRPMLLVDDRALPDFKGIQTSDPNAVVMGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYK
  RKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKT
  GKYRASDEEKINPPPYLTCESFPHAVDHILQHLL

• Structural information:
  • Interpro: IPR036412  IPR006357  IPR023214  IPR006355  
  • CDD: cd07509
  • PDB: 3HLT
  • PDBsum: 3HLT
  • STRING: ENSP00000300605
• Other Databases: GeneCards:  HDHD2  Malacards:  HDHD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016791	phosphatase activity	IBA	molecular function
GO:0016311	dephosphorylation	IBA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016791	phosphatase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0008150	biological_process	ND	biological process
GO:0019899	enzyme binding	IPI	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)