• Gene id: 83699

Gene Summary

• Gene Symbol: SH3BGRL2   Gene   UCSC   Ensembl
• Gene name: SH3 domain binding glutamate rich protein like 2
• Alternate names: SH3 domain-binding glutamic acid-rich-like protein 2, SH3 domain binding glutamic acid-rich protein like 2, fovea-associated SH3 domain-binding protein,
• Gene location: 6q14.1 (79631328: 79703658)     Exons: 5     NC_000006.12
• OMIM: 615678

Protein Summary

• Protein general information: Q9UJC5  
  • Name: SH3 domain binding glutamic acid rich like protein 2 (Fovea associated SH3 domain binding protein)
  • Length: 107  
  • Mass: 12326
  • Tissue specificity: Highly expressed in brain, placenta, liver and kidney. Expressed in retina. {ECO
• Sequence:

  MVIRVFIASSSGFVAIKKKQQDVVRFLEANKIEFEEVDITMSEEQRQWMYKNVPPEKKPTQGNPLPPQIFNGDRY
  CGDYDSFFESKESNTVFSFLGLKPRLASKAEP

• Structural information:
  • Interpro: IPR006993  IPR036249  
  • CDD: cd03030
  • PDB: 2CT6
  • PDBsum: 2CT6
  • STRING: ENSP00000358853
• Other Databases: GeneCards:  SH3BGRL2  Malacards:  SH3BGRL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0017124	SH3 domain binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0031965	nuclear membrane	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)