• Gene id: 83473

Gene Summary

• Gene Symbol: KATNAL2   Gene   UCSC   Ensembl
• Gene name: katanin catalytic subunit A1 like 2
• Alternate names: katanin p60 ATPase-containing subunit A-like 2, katanin catalytic subunit A like 2, katanin p60 subunit A like 2, p60 katanin-like 2,
• Gene location: 18q21.1 (46917549: 47104794)     Exons: 21     NC_000018.10

Protein Summary

• Protein general information: Q8IYT4  
  • Name: Katanin p60 ATPase containing subunit A like 2 (Katanin p60 subunit A like 2) (EC 5.6.1.1) (p60 katanin like 2)
  • Length: 538  
  • Mass: 61253
• Sequence:

  MELSYQTLKFTHQAREACEMRTEARRKNLLILISHYLTQEGYIDTANALEQETKLGLRRFEVCDNIDLETILMEY
  ESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNLPKINQQRPRSKTTAGKTGDTKSLNKEHPNQ
  EVVDNTRLESANFGLHISRIRKDSGEENAHPRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSA
  FIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGK
  TLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLR
  MKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILVDLPSREARQAMIYHWLPPVSKSRALELHTE
  LEYSVLSQETEGYSGSDIKLVCREAAMRPVRKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLA
  QRYSDWQREFESV

• Structural information:
  • Protein Domains: (25..5-)
    (/note="LisH-)
    (/evidence="ECO:0000255|HAMAP-Rule:MF_03025"-)
  • Interpro: IPR003593  IPR041569  IPR003959  IPR027497  IPR006594   IPR027417  
  • Prosite: PS50896
  • STRING: ENSP00000245121
• Other Databases: GeneCards:  KATNAL2  Malacards:  KATNAL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008568	microtubule-severing ATPase activity	IBA	molecular function
GO:0031122	cytoplasmic microtubule organization	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0016887	ATPase activity	IBA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0016853	isomerase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0008568	microtubule-severing ATPase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0000922	spindle pole	IEA	cellular component
GO:0005819	spindle	IEA	cellular component
GO:0008017	microtubule binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0051013	microtubule severing	IEA	biological process
GO:0005874	microtubule	IDA	cellular component
GO:0000922	spindle pole	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005819	spindle	IDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R