• Gene id: 83442

Gene Summary

• Gene Symbol: SH3BGRL3   Gene   UCSC   Ensembl
• Aliases: HEL-S-297, SH3BP-1, TIP-B1
• Gene name: SH3 domain binding glutamate rich protein like 3
• Alternate names: SH3 domain-binding glutamic acid-rich-like protein 3, SH3 domain binding glutamic acid-rich protein like 3, SH3 domain-binding protein 1, SH3BGRL3-like protein, TNF inhibitory protein, epididymis secretory protein Li 297, epididymis secretory sperm binding prot,
• Gene location: 1p36.11 (160419080: 160401640)     Exons: 18     NC_000005.10
• OMIM: 615679

Protein Summary

• Protein general information: Q9H299  
  • Name: SH3 domain binding glutamic acid rich like protein 3 (SH3 domain binding protein 1) (SH3BP 1)
  • Length: 93  
  • Mass: 10438
  • Tissue specificity: Ubiquitous. {ECO
• Sequence:

  MSGLRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDNALRDEMRALAGNPKATPPQIVNGDQYCGDYE
  LFVEAVEQNTLQEFLKLA

• Structural information:
  • Protein Domains: (2..9-)
    (/note="Glutaredoxin-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00686"-)
  • Interpro: IPR006993  IPR002109  IPR036249  
  • Prosite: PS51354
  • CDD: cd03030
  • PDB: 1SJ6
  • PDBsum: 1SJ6
  • STRING: ENSP00000270792
• Other Databases: GeneCards:  SH3BGRL3  Malacards:  SH3BGRL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0015035	protein disulfide oxidoreductase activity	IEA	molecular function
GO:0009055	electron transfer activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016604	nuclear body	IDA	cellular component
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0022900	electron transport chain	IEA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)