• Gene id: 83440

Gene Summary

• Gene Symbol: ADPGK   Gene   UCSC   Ensembl
• Aliases: 2610017G09Rik, ADP-GK
• Gene name: ADP dependent glucokinase
• Alternate names: ADP-dependent glucokinase, ATP-dependent glucokinase, rbBP-35,
• Gene location: 15q24.1 (72783775: 72751293)     Exons: 9     NC_000015.10
• Gene summary(Entrez): ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]
• OMIM: 611861

SNPs

rs3021522

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000012.12   g.2799979C>G
NC_000012.11   g.2909145C>G|SEQ=[C/G]|GENE=FKBP4
ITFG2-AS1   283440

Protein Summary

• Protein general information: Q9BRR6  
  • Name: ADP dependent glucokinase (ADP GK) (ADPGK) (EC 2.7.1.147) (RbBP 35)
  • Length: 497  
  • Mass: 54089
• Sequence:

  MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPAPAPPGPVSPEGRLAAAWDALIVRPVRRWRRV
  AVGVNACVDVVLSGVKLLQALGLSPGNGKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFHDIAQVASEFP
  GAQHYVGGNAALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEWGQLKAPH
  ANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRKRLLEVVTSISDIPTGIPVHLELAS
  MTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQSASGPHSSLSSWNGVPDVGMVSDILFWILKEHGRSKSRASD
  LTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTSRVSLRAPQEFMTSHSEAGSRIVLNPNK
  PVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEVHPHY

• Structural information:
  • Protein Domains: (52..49-)
    (/note="ADPK-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00584"-)
  • Interpro: IPR007666  IPR029056  
  • Prosite: PS51255
  • STRING: ENSP00000312250
• Other Databases: GeneCards:  ADPGK  Malacards:  ADPGK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0006096	glycolytic process	IEA	biological process
GO:0043843	ADP-specific glucokinase activity	IEA	molecular function
GO:0043843	ADP-specific glucokinase activity	IDA	molecular function
GO:0006006	glucose metabolic process	IDA	biological process
GO:0061621	canonical glycolysis	TAS	biological process
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0006096	glycolytic process	IEA	biological process
GO:0016020	membrane	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01200	Carbon metabolism
hsa00010	Glycolysis / Gluconeogenesis

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray