• Gene id: 820

Gene Summary

• Gene Symbol: CAMP   Gene   UCSC   Ensembl
• Aliases: CAP-18, CAP18, CRAMP, FALL-39, FALL39, HSD26, LL37
• Gene name: cathelicidin antimicrobial peptide
• Alternate names: cathelicidin antimicrobial peptide, 18 kDa cationic antimicrobial protein, epididymis secretory sperm binding protein,
• Gene location: 3p21.31 (110814620: 110895712)     Exons: 10     NC_000006.12
• Gene summary(Entrez): This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteo
• OMIM: 600474

Protein Summary

• Protein general information: P49913  
  • Name: Cathelicidin antimicrobial peptide (18 kDa cationic antimicrobial protein) (CAP 18) (hCAP 18) [Cleaved into: Antibacterial peptide FALL 39 (FALL 39 peptide antibiotic); Antibacterial peptide LL 37]
  • Length: 170  
  • Mass: 19301
  • Tissue specificity: Expressed in bone marrow and testis and neutrophils.
• Sequence:

  MKTQRDGHSLGRWSLVLLLLGLVMPLAIIAQVLSYKEAVLRAIDGINQRSSDANLYRLLDLDPRPTMDGDPDTPK
  PVSFTVKETVCPRTTQQSPEDCDFKKDGLVKRCMGTVTLNQARGSFDISCDKDNKRFALLGDFFRKSKEKIGKEF
  KRIVQRIKDFLRNLVPRTES

• Structural information:
  • Interpro: IPR001894  IPR018216  IPR022746  
  • Prosite: PS00946 PS00947
  • PDB: 2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX
  • PDBsum: 2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX
  • STRING: ENSP00000296435
• Other Databases: GeneCards:  CAMP  Malacards:  CAMP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0051873	killing by host of symbiont cells	IDA	biological process
GO:0001530	lipopolysaccharide binding	IBA	molecular function
GO:0050829	defense response to Gram-negative bacterium	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0045087	innate immune response	IBA	biological process
GO:0050830	defense response to Gram-positive bacterium	IBA	biological process
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0006952	defense response	IEA	biological process
GO:0042742	defense response to bacterium	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0042742	defense response to bacterium	IEA	biological process
GO:0042742	defense response to bacterium	TAS	biological process
GO:0051873	killing by host of symbiont cells	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0042742	defense response to bacterium	IMP	biological process
GO:0019730	antimicrobial humoral response	TAS	biological process
GO:0043312	neutrophil degranulation	TAS	biological process
GO:1904724	tertiary granule lumen	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0035580	specific granule lumen	TAS	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0019731	antibacterial humoral response	IDA	biological process
GO:0050830	defense response to Gram-positive bacterium	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0002227	innate immune response in mucosa	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0042581	specific granule	IDA	cellular component
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	biological process
GO:0005615	extracellular space	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04621	NOD-like receptor signaling pathway
hsa05152	Tuberculosis
hsa04970	Salivary secretion
hsa05150	Staphylococcus aureus infection

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray