• Gene id: 8190

Gene Summary

• Gene Symbol: MIA   Gene   UCSC   Ensembl
• Aliases: CD-RAP
• Gene name: MIA SH3 domain containing
• Alternate names: melanoma-derived growth regulatory protein, melanoma inhibitory activity,
• Gene location: 19q13.2 (169270955: 169094258)     Exons: 12     NC_000004.12
• OMIM: 601340

Protein Summary

• Protein general information: Q16674  
  • Name: Melanoma derived growth regulatory protein (Melanoma inhibitory activity protein)
  • Length: 131  
  • Mass: 14509
  • Tissue specificity: All malignant melanoma cell lines tested and infrequently in glioma cell lines.
• Sequence:

  MARSLVCLGVIILLSAFSGPGVRGGPMPKLADRKLCADQECSHPISMAVALQDYMAPDCRFLTIHRGQVVYVFSK
  LKGRGRLFWGGSVQGDYYGDLAARLGYFPSSIVREDQTLKPGKVDVKTDKWDFYCQ

• Structural information:
  • Protein Domains: (43..11-)
    (/note="SH3-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00192"-)
  • Interpro: IPR036028  IPR001452  
  • Prosite: PS50002
  • PDB: 1HJD 1I1J 1K0X 5IXB
  • PDBsum: 1HJD 1I1J 1K0X 5IXB
  • STRING: ENSP00000263369
• Other Databases: GeneCards:  MIA  Malacards:  MIA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030198	extracellular matrix organization	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008083	growth factor activity	IEA	molecular function
GO:0005615	extracellular space	TAS	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)