• Gene id: 81894

Gene Summary

• Gene Symbol: SLC25A28   Gene   UCSC   Ensembl
• Aliases: MFRN2, MRS3/4, MRS4L, NPD016
• Gene name: solute carrier family 25 member 28
• Alternate names: mitoferrin-2, hMRS3/4, mitochondrial RNA splicing protein 3/4, mitochondrial RNA-splicing protein 3/4 homolog, mitochondrial iron transporter 2, putative mitochondrial solute carrier, solute carrier family 25 (mitochondrial iron transporter), member 28,
• Gene location: 10q24.2 (99659506: 99610521)     Exons: 11     NC_000010.11
• OMIM: 609767

Protein Summary

• Protein general information: Q96A46  
  • Name: Mitoferrin 2 (Mitochondrial RNA splicing protein 3/4 homolog) (MRS3/4) (hMRS3/4) (Mitochondrial iron transporter 2) (Solute carrier family 25 member 28)
  • Length: 364  
  • Mass: 39272
  • Tissue specificity: Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart. {ECO
• Sequence:

  MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGGEAGACRPPVRQDPDSGPDYEALPAGATVTTH
  MVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFA
  CYEKLKKTLSDVIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQNEGAGAFY
  RSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAAAATTPLDVCKTLLNTQESLALNSH
  ITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEFFKYLITKRQEEWRAGK

• Structural information:
  • Interpro: IPR018108  IPR023395  
  • Prosite: PS50920
  • STRING: ENSP00000359526
• Other Databases: GeneCards:  SLC25A28  Malacards:  SLC25A28

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0048250	iron import into the mitochondrion	IBA	biological process
GO:0005381	iron ion transmembrane transporter activity	IBA	molecular function
GO:0055072	iron ion homeostasis	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006811	ion transport	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005743	mitochondrial inner membrane	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)