• Gene id: 81875

Gene Summary

• Gene Symbol: ISG20L2   Gene   UCSC   Ensembl
• Aliases: HSD38
• Gene name: interferon stimulated exonuclease gene 20 like 2
• Alternate names: interferon-stimulated 20 kDa exonuclease-like 2, interferon stimulated exonuclease gene 20kDa like 2,
• Gene location: 1q23.1 (156728765: 156721890)     Exons: 5     NC_000001.11
• Gene summary(Entrez): This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014]
• OMIM: 611666

Protein Summary

• Protein general information: Q9H9L3  
  • Name: Interferon stimulated 20 kDa exonuclease like 2 (EC 3.1. . )
  • Length: 353  
  • Mass: 39154
• Sequence:

  MSTLLLNLDFGEPPPKKALEGNAKHRNFVKKRRLLERRGFLSKKNQPPSKAPKLHSEPSKKGETPTVDGTWKTPS
  FPKKKTAASSNGSGQPLDKKAAVSWLTPAPSKKADSVAAKVDLLGEFQSALPKINSHPTRSQKKSSQKKSSKKNH
  PQKNAPQNSTQAHSENKCSGASQKLPRKMVAIDCEMVGTGPKGHVSSLARCSIVNYNGDVLYDEYILPPCHIVDY
  RTRWSGIRKQHMVNATPFKIARGQILKILTGKIVVGHAIHNDFKALQYFHPKSLTRDTSHIPPLNRKADCPENAT
  MSLKHLTKKLLNRDIQVGKSGHSSVEDAQATMELYKLVEVEWEEHLARNPPTD

• Structural information:
  • Protein Domains: (178..35-)
    (/note="Exonuclease"-)
  • Interpro: IPR013520  IPR037433  IPR034933  IPR012337  IPR036397  
  • CDD: cd06149
  • STRING: ENSP00000323424
• Other Databases: GeneCards:  ISG20L2  Malacards:  ISG20L2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004527	exonuclease activity	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0000175	3'-5'-exoribonuclease activity	IEA	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0042254	ribosome biogenesis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0004527	exonuclease activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0000175	3'-5'-exoribonuclease activity	EXP	molecular function
GO:0006364	rRNA processing	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA	biological process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA	biological process
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R