• Gene id: 81617

Gene Summary

• Gene Symbol: CAB39L   Gene   UCSC   Ensembl
• Aliases: MO25-BETA, MO2L, bA103J18.3
• Gene name: calcium binding protein 39 like
• Alternate names: calcium-binding protein 39-like, MO25beta, U937-associated antigen, antigen MLAA-34, mo25-like protein, sarcoma antigen NY-SAR-79,
• Gene location: 13q14.2 (49444850: 49308649)     Exons: 16     NC_000013.11
• OMIM: 612175

Protein Summary

• Protein general information: Q9H9S4  
  • Name: Calcium binding protein 39 like (Antigen MLAA 34) (MO25beta) (Mo25 like protein)
  • Length: 337  
  • Mass: 39088
• Sequence:

  MKKMPLFSKSHKNPAEIVKILKDNLAILEKQDKKTDKASEEVSKSLQAMKEILCGTNEKEPPTEAVAQLAQELYS
  SGLLVTLIADLQLIDFEGKKDVTQIFNNILRRQIGTRSPTVEYISAHPHILFMLLKGYEAPQIALRCGIMLRECI
  RHEPLAKIILFSNQFRDFFKYVELSTFDIASDAFATFKDLLTRHKVLVADFLEQNYDTIFEDYEKLLQSENYVTK
  RQSLKLLGELILDRHNFAIMTKYISKPENLKLMMNLLRDKSPNIQFEAFHVFKVFVASPHKTQPIVEILLKNQPK
  LIEFLSSFQKERTDDEQFADEKNYLIKQIRDLKKTAP

• Structural information:
  • Interpro: IPR011989  IPR016024  IPR013878  
  • PDB: 3ZHP
  • PDBsum: 3ZHP
  • STRING: ENSP00000479669
• Other Databases: GeneCards:  CAB39L  Malacards:  CAB39L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043539	protein serine/threonine kinase activator activity	IBA	molecular function
GO:0035556	intracellular signal transduction	IBA	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0007050	cell cycle arrest	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0071902	positive regulation of protein serine/threonine kinase activity	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04150	mTOR signaling pathway
hsa04152	AMPK signaling pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Male infertility	MIK: 18367176
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R
18367176	Male infertility				Male infertility	Microarray