• Gene id: 80864

Gene Summary

• Gene Symbol: EGFL8   Gene   UCSC   Ensembl
• Aliases: C6orf8, NG3
• Gene name: EGF like domain multiple 8
• Alternate names: epidermal growth factor-like protein 8, EGF-like protein 8, VE-statin-2, vascular endothelial statin-2,
• Gene location: 6p21.32 (116571092: 116500389)     Exons: 7     NC_000001.11
• OMIM: 609897

Protein Summary

• Protein general information: Q99944  
  • Name: Epidermal growth factor like protein 8 (EGF like protein 8) (Vascular endothelial statin 2) (VE statin 2)
  • Length: 293  
  • Mass: 32262
• Sequence:

  MGSRAELCTLLGGFSFLLLLIPGEGAKGGSLRESQGVCSKQTLVVPLHYNESYSQPVYKPYLTLCAGRRICSTYR
  TMYRVMWREVRREVQQTHAVCCQGWKKRHPGALTCEAICAKPCLNGGVCVRPDQCECAPGWGGKHCHVDVDECRT
  SITLCSHHCFNTAGSFTCGCPHDLVLGVDGRTCMEGSPEPPTSASILSVAVREAEKDERALKQEIHELRGRLERL
  EQWAGQAGAWVRAVLPVPPEELQPEQVAELWGRGDRIESLSDQVLLLEERLGACSCEDNSLGLGVNHR

• Structural information:
  • Protein Domains: (34..11-)
    (/note="EMI-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00384-)
    (111..14-)
    (/note="EGF-like-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
    (144..18-)
    (/note="EGF-like-)
    (-)
    (/evidence="ECO:0000255|PROSIT-)
  • Interpro: IPR001881  IPR013032  IPR000742  IPR000152  IPR018097   IPR011489  
  • Prosite: PS00010 PS00022 PS01186 PS50026 PS01187 PS51041
  • STRING: ENSP00000378888
• Other Databases: GeneCards:  EGFL8  Malacards:  EGFL8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001701	in utero embryonic development	ISS	NOT|biological process
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005576	extracellular region	IBA	cellular component
GO:0048856	anatomical structure development	IBA	biological process
GO:0009986	cell surface	IBA	cellular component
GO:0005102	signaling receptor binding	IBA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)