• Gene id: 8079

Gene Summary

• Gene Symbol: MLF2   Gene   UCSC   Ensembl
• Aliases: NTN4
• Gene name: myeloid leukemia factor 2
• Alternate names: myeloid leukemia factor 2, myelodysplasia-myeloid leukemia factor 2,
• Gene location: 12p13.31 (6753140: 6747991)     Exons: 10     NC_000012.12
• OMIM: 601401

Protein Summary

• Protein general information: Q15773  
  • Name: Myeloid leukemia factor 2 (Myelodysplasia myeloid leukemia factor 2)
  • Length: 248  
  • Mass: 28147
  • Tissue specificity: Ubiquitously expressed.
• Sequence:

  MFRFMRDVEPEDPMFLMDPFAIHRQHMSRMLSGGFGYSPFLSITDGNMPGTRPASRRMQQAGAVSPFGMLGMSGG
  FMDMFGMMNDMIGNMEHMTAGGNCQTFSSSTVISYSNTGDGAPKVYQETSEMRSAPGGIRETRRTVRDSDSGLEQ
  MSIGHHIRDRAHILQRSRNHRTGDQEERQDYINLDESEAAAFDDEWRRETSRFRQQRPLEFRRLESSGAGGRRAE
  GPPRLAIQGPEDSPSRQSRRYDW

• Structural information:
  • Interpro: IPR019376  
  • STRING: ENSP00000203630
• Other Databases: GeneCards:  MLF2  Malacards:  MLF2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0006355	regulation of transcription, DNA-templated	IBA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016020	membrane	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq