• Gene id: 80228

Gene Summary

• Gene Symbol: ORAI2   Gene   UCSC   Ensembl
• Aliases: C7orf19, CBCIP2, MEM142B, TMEM142B
• Gene name: ORAI calcium release-activated calcium modulator 2
• Alternate names: protein orai-2, CAP-binding protein complex interacting protein 2, H_NH0514P08.8, putative protein ORAI2-2, transmembrane protein 142B,
• Gene location: 7q22.1 (102433529: 102456824)     Exons: 4     NC_000007.14
• OMIM: 618306

Protein Summary

• Protein general information: Q96SN7  
  • Name: Protein orai 2 (CAP binding protein complex interacting protein 2) (Transmembrane protein 142B)
  • Length: 254  
  • Mass: 28570
• Sequence:

  MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAM
  VAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAW
  GFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRH
  KTERHNREIEELHKLKVQLDGHERSLQVL

• Structural information:
  • Interpro: IPR012446  IPR030034  IPR038350  
  • DIP: 48944
  • STRING: ENSP00000348752
• Other Databases: GeneCards:  ORAI2  Malacards:  ORAI2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002115	store-operated calcium entry	IBA	biological process
GO:0015279	store-operated calcium channel activity	IBA	molecular function
GO:0016020	membrane	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0030426	growth cone	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0070588	calcium ion transmembrane transport	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04020	Calcium signaling pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq