• Gene id: 80179

Gene Summary

• Gene Symbol: MYO19   Gene   UCSC   Ensembl
• Aliases: MYOHD1
• Gene name: myosin XIX
• Alternate names: unconventional myosin-XIX, myosin head domain containing 1, myosin head domain-containing protein 1,
• Gene location: 17q12 (36535456: 36495635)     Exons: 31     NC_000017.11
• OMIM: 617379

Protein Summary

• Protein general information: Q96H55  
  • Name: Unconventional myosin XIX (Myosin head domain containing protein 1)
  • Length: 970  
  • Mass: 109,135
• Sequence:

  MLQQVNGHNPGSDGQAREYLREDLQEFLGGEVLLYKLDDLTRVNPVTLETVLRCLQARYMADTFYTNAGCTLVAL
  NPFKPVPQLYSPELMREYHAAPQPQKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGESGAGKTWTSRCLMKFYA
  VVATSPASWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQQMTGAAVQTYLLEKTRV
  ACQASSERNFHIFYQICKGASEDERLQWHLPEGAAFSWLPNPERSLEEDCFEVTREAMLHLGIDTPTQNNIFKVL
  AGLLHLGNIQFAASEDEAQPCQPMDDAKYSVRTAASLLGLPEDVLLEMVQIRTIRAGRQQQVFRKPCARAECDTR
  RDCLAKLIYARLFDWLVSVINSSICADTDSWTTFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQ
  QEEYAVEGLEWSFINYQDNQPCLDLIEGSPISICSLINEECRLNRPSSAAQLQTRIETALAGSPCLGHNKLSREP
  SFIVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQQSQDPLLMGLFPTNPKEKTQEEPPGQSRAPVLTVVSKFKA
  SLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHRNFVERYKLLRRL
  HPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSML
  ELLECGRARVLEQCARCIQGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMA
  CLAAKELDGVEEKHFSQAPCSLSTSPLQTRLLEAIIRLWPLGLVLANTAMGVGSFQRKLVVWACLQLPRGSPSSY
  TVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRYADICPEPSPYSITGFNQILLERHRLIHVTSSAFTGLG

• Structural information:
  • Protein Domains: Myosin (35-758)
    IQ (759-779)
    IQ (783-812)
  • Interpro: IPR000048  IPR036961  IPR001609  IPR036035  IPR027417  
  • Prosite: PS50096 PS51456
  • CDD: cd14880
  • STRING: ENSP00000409936
• Other Databases: GeneCards:  MYO19  Malacards:  MYO19

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003779	actin binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005741	mitochondrial outer membrane	IEA	cellular component
GO:0016459	myosin complex	IEA	cellular component
GO:0016887	ATPase activity	IEA	molecular function
GO:0032027	myosin light chain binding	IEA	molecular function
GO:0060002	plus-end directed microfilament motor activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0003774	motor activity	IEA	molecular function
GO:0003779	actin binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005741	mitochondrial outer membrane	IEA	cellular component
GO:0005741	mitochondrial outer membrane	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016459	myosin complex	IEA	cellular component
GO:0016459	myosin complex	IEA	cellular component
GO:0016887	ATPase activity	IEA	molecular function
GO:0032027	myosin light chain binding	IEA	molecular function
GO:0060002	plus-end directed microfilament motor activity	IEA	molecular function
GO:0005737	cytoplasm	IDA	cellular component

Diseases

Associated diseases	References
Asthenozoospermia	MIK: 21898990
Asthenospermia	MIK: 21898990
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21898990	Asthenospermia				Male infertility	KIF3B MYO15A KIF6 KIF26B KIF3A DNHD2 DMN DYNC2H1 STARD9 MYOHD1 and TPM1
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)