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Gene id 801
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol CALM1   Gene   UCSC   Ensembl
Aliases CALML2, CAM2, CAM3, CAMB, CAMC, CAMI, CAMIII, CPVT4, DD132, LQT14, PHKD, caM
Gene name calmodulin 1
Alternate names calmodulin-1, Calmodulin-2, Calmodulin-3, calmodulin 1 (phosphorylase kinase, delta), phosphorylase kinase subunit delta, phosphorylase kinase, delta subunit, prepro-calmodulin 1,
Gene location 14q32.11 (90396501: 90408274)     Exons: 8     NC_000012.12
Gene summary(Entrez) This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromos
OMIM 114180

Protein Summary

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04024cAMP signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04114Oocyte meiosis
hsa04218Cellular senescence
hsa04625C-type lectin receptor signaling pathway
hsa04910Insulin signaling pathway
hsa04922Glucagon signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04921Oxytocin signaling pathway
hsa04916Melanogenesis
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04728Dopaminergic synapse
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04744Phototransduction
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04713Circadian entrainment
hsa05200Pathways in cancer
hsa05214Glioma
hsa05010Alzheimer disease
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05418Fluid shear stress and atherosclerosis
hsa05133Pertussis
hsa05152Tuberculosis
hsa05170Human immunodeficiency virus 1 infection
hsa05163Human cytomegalovirus infection
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05200Pathways in cancer
hsa04915Estrogen signaling pathway
hsa04728Dopaminergic synapse
hsa04261Adrenergic signaling in cardiomyocytes
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa05163Human cytomegalovirus infection
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04020Calcium signaling pathway
hsa04218Cellular senescence
hsa04270Vascular smooth muscle contraction
hsa04015Rap1 signaling pathway
hsa04970Salivary secretion
hsa04925Aldosterone synthesis and secretion
hsa04713Circadian entrainment
hsa04910Insulin signaling pathway
hsa05031Amphetamine addiction
hsa04371Apelin signaling pathway
hsa04014Ras signaling pathway
hsa05418Fluid shear stress and atherosclerosis
hsa05034Alcoholism
hsa04114Oocyte meiosis
hsa04916Melanogenesis
hsa05170Human immunodeficiency virus 1 infection
hsa04922Glucagon signaling pathway
hsa05010Alzheimer disease
hsa04070Phosphatidylinositol signaling system
hsa05214Glioma
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa04722Neurotrophin signaling pathway
hsa04971Gastric acid secretion
hsa04720Long-term potentiation
hsa04912GnRH signaling pathway
hsa04625C-type lectin receptor signaling pathway
hsa04924Renin secretion
hsa05152Tuberculosis
hsa04740Olfactory transduction
hsa05133Pertussis
hsa04744Phototransduction

Diseases

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Associated diseases References
Brain ischemia GAD: 19023099
Coronary heart disease GAD: 17975119
Atherosclerosis GAD: 17569884
Scoliosis GAD: 18001530
Osteoarthritis GAD: 16359877
Bulimia GAD: 20468064
Associated with sperm motility, euspermic and infertile asthenozoospermia MIK: 3610359
Role In sperm capacitation MIK: 18488337
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Euspermia MIK: 3610359
Asthenozoospermia MIK: 3610359
Role n sperm capacitation MIK: 18488337
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
18488337 Role n spe
rm capacit
ation

Male infertility
Show abstract
3610359 Associated
with sper
m motility
, euspermi
c and infe
rtile asth
enozoosper
mic

Male infertility
Show abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract