• Gene id: 80018

Gene Summary

• Gene Symbol: NAA25   Gene   UCSC   Ensembl
• Aliases: C12orf30, MDM20, NAP1
• Gene name: N-alpha-acetyltransferase 25, NatB auxiliary subunit
• Alternate names: N-alpha-acetyltransferase 25, NatB auxiliary subunit, N-terminal acetyltransferase B complex subunit NAA25, mitochondrial distribution and morphology 20, natB complex subunit MDM20,
• Gene location: 12q24.13 (112108803: 112026688)     Exons: 25     NC_000012.12
• Gene summary(Entrez): This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]
• OMIM: 612755

Protein Summary

• Protein general information: Q14CX7  
  • Name: N alpha acetyltransferase 25, NatB auxiliary subunit (Mitochondrial distribution and morphology protein 20) (N terminal acetyltransferase B complex subunit MDM20) (NatB complex subunit MDM20) (N terminal acetyltransferase B complex subunit NAA25) (p120)
  • Length: 972  
  • Mass: 112292
• Sequence:

  MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDLHCAKVLKAIGLQRTGKQEEAFTLAQEVAALE
  PTDDNSLQALTILYREMHRPELVTKLYEAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYF
  WSVMSLIMQSISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRGKLGEKLT
  SEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRLIEEAWSPPAEGEHSLEGEVHYSAE
  KAVKFIEDRITEESKSSRHLRGPHLAKLELIRRLRSQGCNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDL
  LPATQCTKFINQLLGVVPLSTPTEDKLALPADIRALQQHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGL
  EFGKTCLKTELQFSDYYCLLAVHALIDVWRETGDETTVWQALTLLEEGLTHSPSNAQFKLLLVRIYCMLGAFEPV
  VDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFALRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFR
  NRLNNSLHFAQVRTERMLLDLLLEANISTSLAESIKSMNLRPEEDDIPWEDLRDNRDLNVFFSWDPKDRDVSEEH
  KKLSLEEETLWLRIRSLTLRLISGLPSLNHPVEPKNSEKTAENGVSSRIDILRLLLQQLEATLETGKRFIEKDIQ
  YPFLGPVPTRMGGFFNSGCSQCQISSFYLVNDIYELDTSGLEDTMEIQERIENSFKSLLDQLKDVFSKCKGDLLE
  VKDGNLKTHPTLLENLVFFVETISVILWVSSYCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTL
  ISNVVDHIKGLETHLIALKLEELILEDTSLSPEERKFSKTVQGKVQSSYLHSLLEMGELLKKRLETTKKLKI

• Structural information:
  • Interpro: IPR019183  IPR013026  IPR011990  
  • Prosite: PS50293
  • DIP: 50826
  • STRING: ENSP00000261745
• Other Databases: GeneCards:  NAA25  Malacards:  NAA25

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004596	peptide alpha-N-acetyltransferase activity	IBA	contributes to
GO:0031416	NatB complex	IBA	cellular component
GO:0017196	N-terminal peptidyl-methionine acetylation	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Type 1 diabetes mellitus	KEGG:H00408
Type 1 diabetes mellitus	KEGG:H00408
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881