• Gene id: 79948

Gene Summary

• Gene Symbol: PLPPR3   Gene   UCSC   Ensembl
• Aliases: LPPR3, LPR3, PRG-2, PRG2
• Gene name: phospholipid phosphatase related 3
• Alternate names: phospholipid phosphatase-related protein type 3, PAP-2-like protein 2, lipid phosphate phosphatase-related protein type 3, plasticity-related gene 2 protein,
• Gene location: 19p13.3 (824243: 810965)     Exons: 9     NC_000019.10
• Gene summary(Entrez): The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration,
• OMIM: 612971

Protein Summary

• Protein general information: Q6T4P5  
  • Name: Phospholipid phosphatase related protein type 3 (EC 3.1.3.4) (Lipid phosphate phosphatase related protein type 3) (PAP 2 like protein 2) (Plasticity related gene 2 protein) (PRG 2)
  • Length: 718  
  • Mass: 76037
• Sequence:

  MISTKEKNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEELIPLLM
  LLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDV
  IQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSMYFNSV
  ISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAEKPAAPAPAK
  DALRALTQRGHDSVYQQNKSVSTDELGPPGRLEGAPRPVAREKTSLGSLKRASVDVDLLAPRSPMAKENMVTFSH
  TLPRASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEE
  EEEEEEEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEK
  SGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPVVHLSAGGA
  PWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPGSSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADG
  ALGPGSRESTLRRHAGGLGLAEREAEAEAEGYFRKMQARRFPD

• Structural information:
  • Interpro: IPR028685  IPR036938  IPR000326  
  • STRING: ENSP00000352962
• Other Databases: GeneCards:  PLPPR3  Malacards:  PLPPR3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006644	phospholipid metabolic process	IBA	biological process
GO:0007165	signal transduction	IBA	biological process
GO:0008195	phosphatidate phosphatase activity	IBA	molecular function
GO:0042577	lipid phosphatase activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0016791	phosphatase activity	IBA	molecular function
GO:0046839	phospholipid dephosphorylation	IBA	biological process
GO:0006644	phospholipid metabolic process	IEA	biological process
GO:0008195	phosphatidate phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0008195	phosphatidate phosphatase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq