• Gene id: 799

Gene Summary

• Gene Symbol: CALCR   Gene   UCSC   Ensembl
• Aliases: CRT, CT-R, CTR, CTR1
• Gene name: calcitonin receptor
• Alternate names: calcitonin receptor,
• Gene location: 7q21.3 (93574729: 93424485)     Exons: 17     NC_000007.14
• Gene summary(Entrez): This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating oste
• OMIM: 602453

Protein Summary

• Protein general information: P30988  
  • Name: Calcitonin receptor (CT R)
  • Length: 474  
  • Mass: 55329
• Sequence:

  MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYVVGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRT
  WDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYY
  LAIVGHSLSIFTLVISLGIFVFFRSLGCQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFF
  HQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYI
  IHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYV
  MHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQEPRNE
  PANNQGEESAEIIPLNIIEQESSA

• Structural information:
  • Interpro: IPR003287  IPR017981  IPR001688  IPR036445  IPR001879   IPR000832  IPR017983  
  • Prosite: PS00649 PS00650 PS50227 PS50261
  • PDB: 5II0 5UZ7 6NIY
  • PDBsum: 5II0 5UZ7 6NIY
  • STRING: ENSP00000352561
• Other Databases: GeneCards:  CALCR  Malacards:  CALCR

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001540	amyloid-beta binding	IC	molecular function
GO:0150058	amylin receptor complex 3	IDA	cellular component
GO:0150056	amylin receptor complex 1	IDA	cellular component
GO:0150057	amylin receptor complex 2	IDA	cellular component
GO:0097643	amylin receptor activity	IGI	contributes to
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:1904645	response to amyloid-beta	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0010628	positive regulation of gene expression	IGI	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IGI	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IGI	biological process
GO:1905665	positive regulation of calcium ion import across plasma membrane	IGI	biological process
GO:1905665	positive regulation of calcium ion import across plasma membrane	IGI	biological process
GO:0010942	positive regulation of cell death	IGI	biological process
GO:0010942	positive regulation of cell death	IGI	biological process
GO:0010739	positive regulation of protein kinase A signaling	IGI	biological process
GO:0051897	positive regulation of protein kinase B signaling	IGI	biological process
GO:0051897	positive regulation of protein kinase B signaling	IGI	biological process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IGI	biological process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	IGI	biological process
GO:0004948	calcitonin receptor activity	IBA	molecular function
GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	biological process
GO:0030424	axon	IBA	cellular component
GO:0005886	plasma membrane	IBA	cellular component
GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA	biological process
GO:0008528	G protein-coupled peptide receptor activity	IBA	molecular function
GO:0097643	amylin receptor activity	IBA	contributes to
GO:0004948	calcitonin receptor activity	IEA	molecular function
GO:0004888	transmembrane signaling receptor activity	IEA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007166	cell surface receptor signaling pathway	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0097647	amylin receptor signaling pathway	IDA	biological process
GO:0051384	response to glucocorticoid	IDA	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	biological process
GO:0032841	calcitonin binding	IDA	molecular function
GO:0032841	calcitonin binding	IDA	NOT|molecular function
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	biological process
GO:0007190	activation of adenylate cyclase activity	IDA	NOT|biological process
GO:0097643	amylin receptor activity	IPI	molecular function
GO:0038041	cross-receptor inhibition within G protein-coupled receptor heterodimer	IPI	biological process
GO:0032841	calcitonin binding	IPI	molecular function
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	NAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0001635	calcitonin gene-related peptide receptor activity	IPI	molecular function
GO:0005887	integral component of plasma membrane	NAS	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa04380	Osteoclast differentiation

Diseases

Associated diseases	References
Osteoporosis	KEGG:H01593
Osteoporosis	KEGG:H01593
Osteoporosis	PMID:23137636
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881