• Gene id: 79841

Gene Summary

• Gene Symbol: AGBL2   Gene   UCSC   Ensembl
• Aliases: CCP2
• Gene name: ATP/GTP binding protein like 2
• Alternate names: cytosolic carboxypeptidase 2, cytoplasmic carboxypeptidase 2, testis tissue sperm-binding protein Li 96mP,
• Gene location: 11p11.2 (47715381: 47659167)     Exons: 24     NC_000011.10
• OMIM: 617345

Protein Summary

• Protein general information: Q5U5Z8  
  • Name: Cytosolic carboxypeptidase 2 (EC 3.4.17. ) (ATP/GTP binding protein like 2)
  • Length: 902  
  • Mass: 104194
• Sequence:

  MFPALETHLKQTIPDPYEDFMYRHLQYYGYFKAQRGSLPNSATHQHVRKNNPQCLLNGSLGEKDDLIPDTLQKEK
  LLWPISLSSAVHRQIEAINRDFHSCLGWMQWRGLSSLQPPPPRFKDSPASAFRVAGITDSHMLSLPHLRSRQLLY
  DELDEVNPRLREPQELFSILSTKRPLQAPRWPIECEVIKENIHHIEWAPPQPEYFYQPKGNEKVPEIVGEKKGTV
  VYQLDSVPIEGSYFTSSRVGGKRGIVKELAVTLQGPEDNTLLFESRFESGNLQKAVRVDTYEYELTLRTDLYTNK
  HTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYTVGMKPLLYSQLDANTRNIGWRREGNEIKYYKNNTDDGQQPFY
  CLTWTIQFPYDQDTCFFAHFYPYTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAA
  AKKAVVLSARVHPGESNGSWVMKGFLDFILSNSPDAQLLRDIFVFKVLPMLNPDGVIVGNYRCSLAGRDLNRHYK
  TILKESFPCIWYTRNMIKRLLEEREVLLYCDFHGHSRKNNIFLYGCNNNNRKYWLHERVFPLMLCKNAPDKFSFH
  SCNFKVQKCKEGTGRVVMWRMGILNSYTMESTFGGSTLGNKRDTHFTIEDLKSLGYHVCDTLLDFCDPDQMKFTQ
  CLAELKELLRQEIHKKFHELGQDVDLEGSWSDISLSDIESSTSGSDSSLSDGLPVHLANIADELTQKKKMFKKKK
  KKSLQTRKQRNEQYQKKNLMQKLKLTEDTSEKAGFASTLQKQPTFFKNSENSSFLPMKNENPRLNETNLNRRDKD
  TPLDPSMATLILPKNKGRMQNKKPGFTVSCSPKRTINSSQEPAPGMKPNWPRSRYPATKRGCAAMAAYPSLHIYT
  YP

• Structural information:
  • Interpro: IPR040626  IPR000834  
  • STRING: ENSP00000435582
• Other Databases: GeneCards:  AGBL2  Malacards:  AGBL2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004181	metallocarboxypeptidase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0035608	protein deglutamylation	IBA	biological process
GO:0035610	protein side chain deglutamylation	IBA	biological process
GO:0036064	ciliary basal body	IDA	cellular component
GO:0005814	centriole	IDA	cellular component
GO:0004181	metallocarboxypeptidase activity	ISS	molecular function
GO:0005829	cytosol	ISS	cellular component
GO:0035610	protein side chain deglutamylation	ISS	biological process
GO:0004181	metallocarboxypeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008270	zinc ion binding	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0004180	carboxypeptidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0005829	cytosol	IEA	cellular component
GO:0004181	metallocarboxypeptidase activity	IEA	molecular function
GO:0035610	protein side chain deglutamylation	IEA	biological process
GO:0005829	cytosol	IEA	cellular component
GO:0005814	centriole	IEA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R