• Gene id: 79836

Gene Summary

• Gene Symbol: LONRF3   Gene   UCSC   Ensembl
• Aliases: RNF127
• Gene name: LON peptidase N-terminal domain and ring finger 3
• Alternate names: LON peptidase N-terminal domain and RING finger protein 3, ring finger protein 127,
• Gene location: Xq24 (118974613: 119022924)     Exons: 13     NC_000023.11
• Gene summary(Entrez): The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants hav

Protein Summary

• Protein general information: Q496Y0  
  • Name: LON peptidase N terminal domain and RING finger protein 3 (RING finger protein 127)
  • Length: 759  
  • Mass: 84490
• Sequence:

  MESVRIEQMLSLPAEVSSDNLESAERGASAAQVDMGPHPKVAAEGPAPLPTREPEQEQSPGTSTPESKVLLTQAD
  ALASRGRIREALEVYRQLSERQQLVAEQLEQLVRCLAEKVPQGEALAPAPPDEGSTASGTVAAEETGAAAAAAAT
  EVWDGFKCRKCHGFLSDPVSLSCGHTFCKLCLERGRAADRRCALCGVKLSALMVATGRARGARRAGQQPPPPLRV
  NVVLSGLLGKLFPGPARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHLLYSNRSQIYFTLESHENALHDA
  EIACKLRPMGFKAHFRKAQALATLGKVEEALREFLYCVSLDGKNKRARCEAQRDNLELPHCSSQEEAAARGDGSS
  LMDPAKVKGDGQQHHMKDQEEEEEKWDATSPKAASSKTGKCQEKKRKHCQIESQEETGMPNKASKQDPPTDQGDK
  PALSLPLASFDASDLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGLSQCLASRKYSKNVIMEE
  LIAKFLPEELKERRKLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGD
  PVKGFAEYGCILEIRNVQFFADGRSVVDSIGKRRFRVLHQSQRDGYNTADIEYIEDQKVQGEDCAELMGLHNCVY
  QQASLWFHSLKLSLKNRILNHFGPMPEKDADPQMNPNGPAWCWWMLAVLPLESRAQLPFLAMRSLKDRLNGIRRV
  LAFISRNQN

• Structural information:
  • Protein Domains: (553..75-)
    (/note="Lon-N-terminal)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU01123"-)
  • Interpro: IPR003111  IPR015947  IPR013026  IPR011990  IPR019734   IPR001841  IPR013083  IPR017907  
  • Prosite: PS51787 PS50005 PS50293 PS00518 PS50089
  • STRING: ENSP00000360690
• Other Databases: GeneCards:  LONRF3  Malacards:  LONRF3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0046872	metal ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881