• Gene id: 79823

Gene Summary

• Gene Symbol: CAMKMT   Gene   UCSC   Ensembl
• Aliases: C2orf34, CLNMT, CaM KMT, Cam, KMT
• Gene name: calmodulin-lysine N-methyltransferase
• Alternate names: calmodulin-lysine N-methyltransferase,
• Gene location: 2p21 (44361713: 44772591)     Exons: 27     NC_000002.12
• Gene summary(Entrez): This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]
• OMIM: 600928

Protein Summary

• Protein general information: Q7Z624  
  • Name: Calmodulin lysine N methyltransferase (CLNMT) (CaM KMT) (EC 2.1.1.60)
  • Length: 323  
  • Mass: 36128
  • Tissue specificity: Isoform 1 is expressed in brain, liver, muscle colon and lung. Isoform 2 is expressed in colon, testis, kidney and brain. Isoform 1 and isoform 2 are expressed in normal lymphoblastoid cells but not in lymphoblastoid cells from patient
• Sequence:

  MESRVADAGTGETARAAGGSPAVGCTTRGPVVSAPLGAARWKLLRQVLKQKHLDDCLRHVSVRRFESFNLFSVTE
  GKERETEEEVGAWVQYTSIFCPEYSISLRHNSGSLNVEDVLTSFDNTGNVCIWPSEEVLAYYCLKHNNIFRALAV
  CELGGGMTCLAGLMVAISADVKEVLLTDGNEKAIRNVQDIITRNQKAGVFKTQKISSCVLRWDNETDVSQLEGHF
  DIVMCADCLFLDQYRASLVDAIKRLLQPRGKAMVFAPRRGNTLNQFCNLAEKAGFCIQRHENYDEHISNFHSKLK
  KENPDIYEENLHYPLLLILTKHG

• Structural information:
  • Interpro: IPR025800  IPR019410  IPR029063  
  • Prosite: PS51610
  • PDB: 4PWY
  • PDBsum: 4PWY
  • STRING: ENSP00000367755
• Other Databases: GeneCards:  CAMKMT  Malacards:  CAMKMT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0018025	calmodulin-lysine N-methyltransferase activity	IBA	molecular function
GO:0018025	calmodulin-lysine N-methyltransferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0032259	methylation	IEA	biological process
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0016740	transferase activity	IEA	molecular function
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0018025	calmodulin-lysine N-methyltransferase activity	IEA	molecular function
GO:0022400	regulation of rhodopsin mediated signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0006479	protein methylation	TAS	biological process
GO:0018025	calmodulin-lysine N-methyltransferase activity	TAS	molecular function
GO:0007005	mitochondrion organization	IEA	biological process
GO:0018025	calmodulin-lysine N-methyltransferase activity	IEA	molecular function
GO:0018022	peptidyl-lysine methylation	IEA	biological process
GO:0005794	Golgi apparatus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0032991	protein-containing complex	IDA	cellular component
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00310	Lysine degradation

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq