• Gene id: 79819

Gene Summary

• Gene Symbol: DNAI4   Gene   UCSC   Ensembl
• Aliases: DIC4, WDR78
• Gene name: dynein axonemal intermediate chain 4
• Alternate names: WD repeat-containing protein 78, WD repeat domain 78,
• Gene location: 1p31.3 (66924855: 66812884)     Exons: 10     NC_000001.11

Protein Summary

• Protein general information: Q5VTH9  
  • Name: WD repeat containing protein 78
  • Length: 848  
  • Mass: 94573
• Sequence:

  MTPGKHSGASARAANGGAWGYRDFRGGQKKGWCTTPQLVATMPVSPAGSHKQQNFGLNNATQPKKSISFFATMKA
  TSVKGYTGANQSRMAVSKTVLIPPELKTVEKPNPNIKTTQVFDINGTDVTPRPLYHPDPLTGTAKPSKLLTSQEG
  SLGSEFISSYSLYQNTINPSTLGQFTRSVLGSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQVIRAAPEK
  IVTKEDLEKNIEIILTETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKN
  KDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQDQRLPGSTTEKNSETSSLMDI
  ENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVE
  EESKKEEEEEIHAEESTIPANLERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKN
  PMWPERIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRGT
  TGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQAPGMCFAFHPKDTNI
  YLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVV
  YDVAWSPKSSYIFAAANENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMP
  TVLETGRGDIMDTLLGSKSNQSA

• Structural information:
  • Interpro: IPR015943  IPR001680  IPR017986  IPR036322  
  • Prosite: PS50082 PS50294
  • STRING: ENSP00000360065
• Other Databases: GeneCards:  DNAI4  Malacards:  DNAI4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005858	axonemal dynein complex	IBA	cellular component
GO:0007018	microtubule-based movement	IBA	biological process
GO:0045503	dynein light chain binding	IBA	molecular function
GO:0003341	cilium movement	IBA	biological process
GO:0045504	dynein heavy chain binding	IBA	molecular function
GO:0002244	hematopoietic progenitor cell differentiation	IEA	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray