• Gene id: 79807

Gene Summary

• Gene Symbol: GSTCD   Gene   UCSC   Ensembl
• Gene name: glutathione S-transferase C-terminal domain containing
• Alternate names: glutathione S-transferase C-terminal domain-containing protein,
• Gene location: 4q24 (105708777: 105847725)     Exons: 14     NC_000004.12
• OMIM: 615912

Protein Summary

• Protein general information: Q8NEC7  
  • Name: Glutathione S transferase C terminal domain containing protein
  • Length: 633  
  • Mass: 71079
  • Tissue specificity: Widely expressed in cell types relevant to airway function, including airway smooth muscle cells and epithelial cells. {ECO
• Sequence:

  MKAIKKSLTEEEYLYLDFSHQTEGCIFPLHTSVTLFLLSYCDCKIFKICLVVTKEVSRDSSLLRDDLIQDVEIQI
  ISRQELPPIVQNCCLPAVVERSDNFCRAGLAVVLRHIIQKSYEADPLKKELLELLGFKKTCLKACAEVSQWTRLC
  ELTIPLAIENFLRESSDQPPTIPVEILQLEKKLSEPVRVHNDDKLRRQKLKQQKADGVGPPLTKGKAKSKVHTQE
  TSEGLDSSSKSLELKVAFSKLTVQEEPATTNREPSHIRKAKASDLPPLEHVFAEGLYFTLADIVLLPCIHHFLVI
  ISRKFSEKLVEFPLLASWYQRIQEVPGVKTAASKCGIQFLHLPKLLTTSTEQHPNLCEVPGVEEQSDPLFIGGPR
  PTMAKLMEKGIEVMFSPHPCPTWTLDWNVLPAAVSPKEGKMSSDRALRKQQQLNNLVYVVTNQAKPGDRIVDFCS
  GGGHVGIVLAHMLPSCQVTLIENKELSLIRAKKRSDELGLSNIWFIQANMEYFTGMFNIGVALHACGVATDMVIE
  HCIKTRASFVTCPCCYGFIQNTSKFNFPKSEQFKKTLSYKEHMILCRFADQTAVQLPPQRRLIGKQCMCLVDLDR
  ARAAEECGYSVQVISMEPESCSPKNNMIVGVPI

• Structural information:
  • Protein Domains: (130..33-)
    (/note="GST-C-terminal")
  • Interpro: IPR010987  IPR036282  IPR025714  IPR029063  
  • Prosite: PS50405
  • STRING: ENSP00000422354
• Other Databases: GeneCards:  GSTCD  Malacards:  GSTCD

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003674	molecular_function	ND	molecular function
GO:0008150	biological_process	ND	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R