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Gene id 79789
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary

Gene Symbol CLMN   Gene   UCSC   Ensembl
Gene name calmin
Alternate names calmin, calmin (calponin-like, transmembrane), calponin-like transmembrane domain protein,
Gene location 14q32.13 (95319907: 95181939)     Exons: 17     NC_000014.9
OMIM 611121

Protein Summary

Protein general information Q96JQ2  

Name: Calmin (Calponin like transmembrane domain protein)

Length: 1002  Mass: 111651

Tissue specificity: Widely expressed at intermediate level. {ECO

Sequence MAAHEWDWFQREELIGQISDIRVQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVL
SGRNLLHEYKSSSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKELTGNLSRN
SPSSSLSPGSGGTDSDSSFPPTPTAERSVAISVKDQRKAIKALLAWVQRKTRKYGVAVQDFAGSWRSGLAFLAVI
KAIDPSLVDMKQALENSTRENLEKAFSIAQDALHIPRLLEPEDIMVDTPDEQSIMTYVAQFLERFPELEAEDIFD
SDKEVPIESTFVRIKETPSEQESKVFVLTENGERTYTVNHETSHPPPSKVFVCDKPESMKEFRLDGVSSHALSDS
STEFMHQIIDQVLQGGPGKTSDISEPSPESSILSSRKENGRSNSLPIKKTVHFEADTYKDPFCSKNLSLCFEGSP
RVAKESLRQDGHVLAVEVAEEKEQKQESSKIPESSSDKVAGDIFLVEGTNNNSQSSSCNGALESTARHDEESHSL
SPPGENTVMADSFQIKVNLMTVEALEEGDYFEAIPLKASKFNSDLIDFASTSQAFNKVPSPHETKPDEDAEAFEN
HAEKLGKRSIKSAHKKKDSPEPQVKMDKHEPHQDSGEEAEGCPSAPEETPVDKKPEVHEKAKRKSTRPHYEEEGE
DDDLQGVGEELSSSPPSSCVSLETLGSHSEEGLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAVLEAYVEDPEDL
KNEEMDLEEPEGYMPDLDSREEEADGSQSSSSSSVPGESLPSASDQVLYLSRGGVGTTPASEPAPLAPHEDHQQR
ETKENDPMDSHQSQESPNLENIANPLEENVTKESISSKKKEKRKHVDHVESSLFVAPGSVQSSDDLEEDSSDYSI
PSRTSHSDSSIYLRRHTHRSSESDHFSYVQLRNAADLDDRRNRILTRKANSSGEAMSLGSHSPQSDSLTQLVQQP
DMMYFILFLWLLVYCLLLFPQLDVSRL
Structural information
Protein Domains
(32..13-)
1 (/note="Calponin-homology-(CH))
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00044-)
(187..29-)
2 (/note="Calponin-homology-(CH))
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00044"-)
Interpro:  IPR001589  IPR001715  IPR036872  
Prosite:   PS00019 PS00020 PS50021
CDD:   cd00014
STRING:   ENSP00000298912
Other Databases GeneCards:  CLMN  Malacards:  CLMN

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0051647 nucleus localization
IBA biological process
GO:0051015 actin filament binding
IBA molecular function
GO:0034993 meiotic nuclear membrane
microtubule tethering com
plex
IBA cellular component
GO:0008285 negative regulation of ce
ll population proliferati
on
IBA biological process
GO:0007097 nuclear migration
IBA biological process
GO:0005737 cytoplasm
IBA cellular component
GO:0005640 nuclear outer membrane
IBA cellular component
GO:0003779 actin binding
IEA molecular function
GO:0016021 integral component of mem
brane
IEA cellular component
GO:0016020 membrane
IEA cellular component
GO:0008285 negative regulation of ce
ll population proliferati
on
IEA biological process
GO:0031175 neuron projection develop
ment
IEA biological process
GO:0005737 cytoplasm
IEA cellular component
GO:0016020 membrane
IEA cellular component
Associated diseases References
Cryptorchidism MIK: 28606200
Spermatogenic defects MIK: 31037746
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
28606200 Cryptorchi
dism

Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
Male infertility MeDIP-Seq
Show abstract
31037746 Spermatoge
nic defect
s

16 (1 control,
15 cases)
Male infertility GSE6023 analyzed using GEO2R
Show abstract