• Gene id: 79745

Gene Summary

• Gene Symbol: CLIP4   Gene   UCSC   Ensembl
• Aliases: RSNL2
• Gene name: CAP-Gly domain containing linker protein family member 4
• Alternate names: CAP-Gly domain-containing linker protein 4, CAP-GLY domain containing linker protein family, member 4, restin-like protein 2,
• Gene location: 2p23.2 (29097675: 29183807)     Exons: 23     NC_000002.12
• OMIM: 0

Protein Summary

• Protein general information: Q8N3C7  
  • Name: CAP Gly domain containing linker protein 4 (Restin like protein 2)
  • Length: 705  
  • Mass: 76317
• Sequence:

  MTIEDLPDFPLEGNPLFGRYPFIFSASDTPVIFSISAAPMPSDCEFSFFDPNDASCQEILFDPKTSVSELFAILR
  QWVPQVQQNIDIIGNEILKRGCNVNDRDGLTDMTLLHYTCKSGAHGIGDVETAVKFATQLIDLGADISLRSRWTN
  MNALHYAAYFDVPELIRVILKTSKPKDVDATCSDFNFGTALHIAAYNLCAGAVKCLLEQGANPAFRNDKGQIPAD
  VVPDPVDMPLEMADAAATAKEIKQMLLDAVPLSCNISKAMLPNYDHVTGKAMLTSLGLKLGDRVVIAGQKVGTLR
  FCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPLIRSQ
  KIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSN
  KKTMSKSPSLSSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGK
  NDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASSQKEINRRNAFSKS
  KAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYF
  TCKPNHGVLVRPSRVTYRGINGSKLVDENC

• Structural information:
  • Protein Domains: (303..34-)
    (/note="CAP-Gly-1)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00045-)
    (505..54-)
    (/note="CAP-Gly-2)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00045-)
    (644..68-)
    (/note="CAP-Gly-3)
    (/evidence="ECO:0000255|PROSITE-ProRule:PR-)
  • Interpro: IPR002110  IPR020683  IPR036770  IPR036859  IPR000938  
  • Prosite: PS50297 PS50088 PS00845 PS50245
  • PDB: 2Z0W
  • PDBsum: 2Z0W
  • STRING: ENSP00000327009
• Other Databases: GeneCards:  CLIP4  Malacards:  CLIP4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031122	cytoplasmic microtubule organization	IBA	biological process
GO:0005938	cell cortex	IBA	cellular component
GO:0051010	microtubule plus-end binding	IBA	molecular function
GO:0035371	microtubule plus-end	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R