• Gene id: 79733

Gene Summary

• Gene Symbol: E2F8   Gene   UCSC   Ensembl
• Aliases: E2F-8
• Gene name: E2F transcription factor 8
• Alternate names: transcription factor E2F8, E2F family member 8,
• Gene location: 11p15.1 (19241654: 19224062)     Exons: 14     NC_000011.10
• Gene summary(Entrez): This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the pro
• OMIM: 300917

Protein Summary

• Protein general information: A0AVK6  
  • Name: Transcription factor E2F8 (E2F 8)
  • Length: 867  
  • Mass: 94166
• Sequence:

  MENEKENLFCEPHKRGLMKTPLKESTTANIVLAEIQPDFGPLTTPTKPKEGSQGEPWTPTANLKMLISAVSPEIR
  NRDQKRGLFDNRSGLPEAKDCIHEHLSGDEFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEEL
  NVERRRIYDIVNVLESLHMVSRLAKNRYTWHGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYS
  IEDHIIKSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHV
  EDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNTSGSSPVIHFTPSDLEVRRSSK
  ENCAKNLFSTRGKPNFTRHPSLIKLVKSIESDRRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICKMQLEE
  QSSESRQKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYL
  QPTQAHQSVTPPQGLSPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAG
  ERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENSSALSPNHRIYSSPIA
  GVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALASSHPVPIQNPSSAIVNFTLQHLGLISPNVQL
  SASPGSGIVPVSPRIESVNVAPENAGTQQGRATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFR
  TPGGPTKPTSSSCMDFEGANKTSLGTLFVPQRKLEVSTEDVH

• Structural information:
  • Interpro: IPR015633  IPR003316  IPR036388  IPR036390  
  • PDB: 4YO2
  • PDBsum: 4YO2
  • STRING: ENSP00000481103
• Other Databases: GeneCards:  E2F8  Malacards:  E2F8

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000790	nuclear chromatin	ISA	cellular component
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	biological process
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	molecular function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	molecular function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	molecular function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	biological process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	molecular function
GO:0003677	DNA binding	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0008134	transcription factor binding	IBA	molecular function
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	biological process
GO:0003700	DNA-binding transcription factor activity	IBA	molecular function
GO:0043565	sequence-specific DNA binding	IBA	molecular function
GO:0051726	regulation of cell cycle	IBA	biological process
GO:0090575	RNA polymerase II transcription regulator complex	IBA	cellular component
GO:0060718	chorionic trophoblast cell differentiation	ISS	biological process
GO:0033301	cell cycle comprising mitosis without cytokinesis	ISS	biological process
GO:0032877	positive regulation of DNA endoreduplication	ISS	biological process
GO:0001217	DNA-binding transcription repressor activity	ISS	molecular function
GO:0003700	DNA-binding transcription factor activity	IMP	molecular function
GO:0002040	sprouting angiogenesis	IMP	biological process
GO:0001890	placenta development	ISS	biological process
GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	molecular function
GO:0070365	hepatocyte differentiation	ISS	biological process
GO:0060707	trophoblast giant cell differentiation	ISS	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	biological process
GO:0032466	negative regulation of cytokinesis	ISS	biological process
GO:0000122	negative regulation of transcription by RNA polymerase II	ISS	biological process
GO:0003700	DNA-binding transcription factor activity	IEA	molecular function
GO:0005667	transcription regulator complex	IEA	cellular component
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0060718	chorionic trophoblast cell differentiation	IEA	biological process
GO:0033301	cell cycle comprising mitosis without cytokinesis	IEA	biological process
GO:0032877	positive regulation of DNA endoreduplication	IEA	biological process
GO:0003700	DNA-binding transcription factor activity	IEA	molecular function
GO:0002040	sprouting angiogenesis	IEA	biological process
GO:0001890	placenta development	IEA	biological process
GO:0070365	hepatocyte differentiation	IEA	biological process
GO:0060707	trophoblast giant cell differentiation	IEA	biological process
GO:0042802	identical protein binding	IEA	molecular function
GO:0032466	negative regulation of cytokinesis	IEA	biological process
GO:0008283	cell population proliferation	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0003714	transcription corepressor activity	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0000122	negative regulation of transcription by RNA polymerase II	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881