• Gene id: 79713

Gene Summary

• Gene Symbol: IGFLR1   Gene   UCSC   Ensembl
• Aliases: TMEM149
• Gene name: IGF like family receptor 1
• Alternate names: IGF-like family receptor 1, transmembrane protein 149,
• Gene location: 19q13.12 (35742451: 35738800)     Exons: 5     NC_000019.10
• OMIM: 614143

Protein Summary

• Protein general information: Q9H665  
  • Name: IGF like family receptor 1 (Transmembrane protein 149) (U2 small nuclear RNA auxiliary factor 1 like 4)
  • Length: 355  
  • Mass: 37895
• Sequence:

  MGPGRCLLTALLLLALAPPPEASQYCGRLEYWNPDNKCCSSCLQRFGPPPCPDYEFRENCGLNDHGDFVTPPFRK
  CSSGQCNPDGAELCSPCGGGAVTPTPAAGGGRTPWRCRERPVPAKGHCPLTPGNPGAPSSQERSSPASSIAWRTP
  EPVPQQAWPNFLPLVVLVLLLTLAVIAILLFILLWHLCWPKEKADPYPYPGLVCGVPNTHTPSSSHLSSPGALET
  GDTWKEASLLPLLSRELSSLASQPLSRLLDELEVLEELIVLLDPEPGPGGGMAHGTTRHLAARYGLPAAWSTFAY
  SLRPSRSPLRALIEMVVAREPSASLGQLGTHLAQLGRADALRVLSKLGSSGVCWA

• Structural information:
  • Interpro: IPR011029  IPR042355  
  • STRING: ENSP00000246532
• Other Databases: GeneCards:  IGFLR1  Malacards:  IGFLR1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005886	plasma membrane	IBA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881