• Gene id: 79710

Gene Summary

• Gene Symbol: MORC4   Gene   UCSC   Ensembl
• Aliases: ZCW4, ZCWCC2, dJ75H8.2
• Gene name: MORC family CW-type zinc finger 4
• Alternate names: MORC family CW-type zinc finger protein 4, zinc finger CW-type coiled-coil domain protein 2, zinc finger CW-type domain protein 4, zinc finger, CW type with coiled-coil domain 2,
• Gene location: Xq22.3 (107000243: 106940299)     Exons: 17     NC_000023.11
• Gene summary(Entrez): In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stra
• OMIM: 300970

Protein Summary

• Protein general information: Q8TE76  
  • Name: MORC family CW type zinc finger protein 4 (Zinc finger CW type coiled coil domain protein 2) (Zinc finger CW type domain protein 4)
  • Length: 937  
  • Mass: 106348
  • Tissue specificity: Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas. {ECO
• Sequence:

  MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDNAVDPDVSARTVFIDV
  EEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGVFGNGFKSGSMRLGKDALVFTKNGGTLTVGL
  LSQTYLECVQAQAVIVPIVPFNQQNKKMIITEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRR
  NKNGKSELDFDTDQYDILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIAKSLA
  NVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRGEGVGVIGVIECNFLKPAYN
  KQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFETSTVARPIPKVPDQTWVQCDECLKWRKLPGKIDPSMLPAR
  WFCYYNSHPKYRRCSVPEEQELTDEDLCLSKAKKQEQTVEEKKKMPMENENHQVFSNPPKILTVQEMAGLNNKTI
  GYEGIHSPSVLPSGGEESRSPSLQLKPLDSSVLQFSSKYKWILGEEPVEKRRRLQNEMTTPSLDYSMPAPYRRVE
  APVAYPEGENSHDKSSSERSTPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGSLLPEELEDQMPRLVAEESN
  RGSTTINKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAERRKAVESWNPVPYSVASAAIPAAAIGEKAR
  GYEESEGHNTPKLKNQRELEELKRTTEKLERVLAERNLFQQKVEELEQERNHWQSEFKKVQHELVIYSTQEAEGL
  YWSKKHMGYRQAEFQILKAELERTKEEKQELKEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVS
  YLLTSVLPHLELREIGYDSEQVDGILYTVLEANHILD

• Structural information:
  • Interpro: IPR036890  IPR041006  IPR011124  
  • Prosite: PS51050
  • STRING: ENSP00000347821
• Other Databases: GeneCards:  MORC4  Malacards:  MORC4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008270	zinc ion binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)