• Gene id: 797

Gene Summary

• Gene Symbol: CALCB   Gene   UCSC   Ensembl
• Aliases: CALC2, CGRP-II, CGRP2
• Gene name: calcitonin related polypeptide beta
• Alternate names: calcitonin gene-related peptide 2, beta-CGRP, beta-type CGRP, calcitonin 2, calcitonin gene-related peptide II,
• Gene location: 11p15.2 (15073592: 15078636)     Exons: 5     NC_000011.10

Protein Summary

• Protein general information: P10092  
  • Name: Calcitonin gene related peptide 2 (Beta type CGRP) (Beta CGRP) (Calcitonin gene related peptide II) (CGRP II)
  • Length: 127  
  • Mass: 13706
• Sequence:

  MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSS
  SAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRRRDLQA

• Structural information:
  • Interpro: IPR021117  IPR021116  IPR018360  IPR015476  IPR001693  
  • Prosite: PS00258
  • STRING: ENSP00000433490
• Other Databases: GeneCards:  CALCB  Malacards:  CALCB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031716	calcitonin receptor binding	IBA	molecular function
GO:0005615	extracellular space	IBA	cellular component
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	biological process
GO:0051480	regulation of cytosolic calcium ion concentration	IBA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005179	hormone activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005179	hormone activity	IEA	molecular function
GO:0005184	neuropeptide hormone activity	TAS	molecular function
GO:0006874	cellular calcium ion homeostasis	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04080	Neuroactive ligand-receptor interaction
hsa04270	Vascular smooth muscle contraction

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881