• Gene id: 79699

Gene Summary

• Gene Symbol: ZYG11B   Gene   UCSC   Ensembl
• Aliases: ZYG11
• Gene name: zyg-11 family member B, cell cycle regulator
• Alternate names: protein zyg-11 homolog B, zyg-11 homolog B,
• Gene location: 1p32.3 (86100200: 86026140)     Exons: 11     NC_000009.12
• OMIM: 618673

Protein Summary

• Protein general information: Q9C0D3  
  • Name: Protein zyg 11 homolog B
  • Length: 744  
  • Mass: 83921
• Sequence:

  MPEDQAGAAMEEASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGI
  FRGNQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSL
  EDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESLDISNTSITDITALLACKDRLKSLTMHHLKCLKMT
  TTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTDKAVEAFIQQRPSMQFVGLL
  ATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMRNHPM
  NLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAK
  LVMQWLCNHEDQNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLT
  DESPTTCRHFIENQGLELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSY
  FAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQ
  HVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILDSLEKHIVRHGRPPPCKKQPQARLN

• Structural information:
  • Interpro: IPR011989  IPR016024  IPR001611  IPR032675  IPR040367  
  • Prosite: PS51450
  • STRING: ENSP00000294353
• Other Databases: GeneCards:  ZYG11B  Malacards:  ZYG11B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031462	Cul2-RING ubiquitin ligase complex	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0031462	Cul2-RING ubiquitin ligase complex	IBA	cellular component
GO:0031462	Cul2-RING ubiquitin ligase complex	IDA	cellular component
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	biological process
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	IMP	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)