Gene id |
79691 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
Gene Symbol |
QTRT2 Gene UCSC Ensembl |
Aliases |
QTRTD1 |
Gene name |
queuine tRNA-ribosyltransferase accessory subunit 2 |
Alternate names |
queuine tRNA-ribosyltransferase accessory subunit 2, queuine tRNA-ribosyltransferase domain containing 1, |
Gene location |
3q13.31 (75647686: 75627723) Exons: 15 NC_000016.10
|
Gene summary(Entrez) |
This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code
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Protein Summary
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Protein general information
| Q9H974
Name: Queuine tRNA ribosyltransferase accessory subunit 2 (Queuine tRNA ribosyltransferase domain containing protein 1)
Length: 415 Mass: 46713
|
Sequence |
MKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLHNIHGVPAMAQLTLSSLAEHHEVLT EYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWSVAGRVEMTVSKFMAIQKALQPDWFQCLSDGEVS CKEATSIKRVRKSVDRSLLFLDNCLRLQEESEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGN PTTLEARLRLLSSVTAELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETL LQQNGTQEEIKCMDQIKKIETTGCNQEITSFEINLKEKKYQEDFNPLVRGCSCYCCKNHTRAYIHHLLVTNELLA GVLLMMHNFEHYFGFFHYIREALKSDKLAQLKELIHRQAS
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Structural information |
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Other Databases |
GeneCards: QTRT2 Malacards: QTRT2 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0101030 |
tRNA-guanine transglycosy lation
|
IBA |
biological process |
GO:0008479 |
queuine tRNA-ribosyltrans ferase activity
|
IC |
contributes to |
GO:0101030 |
tRNA-guanine transglycosy lation
|
IDA |
biological process |
GO:0042803 |
protein homodimerization activity
|
IDA |
molecular function |
GO:0046982 |
protein heterodimerizatio n activity
|
IDA |
molecular function |
GO:0032991 |
protein-containing comple x
|
IPI |
cellular component |
GO:0005739 |
mitochondrion
|
ISS |
cellular component |
GO:0005737 |
cytoplasm
|
ISS |
cellular component |
GO:0008479 |
queuine tRNA-ribosyltrans ferase activity
|
IEA |
molecular function |
GO:0006400 |
tRNA modification
|
IEA |
biological process |
GO:0016763 |
transferase activity, tra nsferring pentosyl groups
|
IEA |
molecular function |
GO:0008033 |
tRNA processing
|
IEA |
biological process |
GO:0046872 |
metal ion binding
|
IEA |
molecular function |
GO:0005739 |
mitochondrion
|
IEA |
cellular component |
GO:0016020 |
membrane
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0005741 |
mitochondrial outer membr ane
|
IEA |
cellular component |
GO:0005741 |
mitochondrial outer membr ane
|
TAS |
cellular component |
GO:0006400 |
tRNA modification
|
TAS |
biological process |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0005741 |
mitochondrial outer membr ane
|
IEA |
cellular component |
GO:0008479 |
queuine tRNA-ribosyltrans ferase activity
|
IEA |
molecular function |
GO:0101030 |
tRNA-guanine transglycosy lation
|
IEA |
biological process |
GO:0005741 |
mitochondrial outer membr ane
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
|
|
Associated diseases |
References |
Teratozoospermia | MIK: 17327269 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
17327269 |
Teratozoos permia
|
|
|
13 (5 controls, 8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
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Show abstract |
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