• Gene id: 79609

Gene Summary

• Gene Symbol: VCPKMT   Gene   UCSC   Ensembl
• Aliases: C14orf138, METTL21D, VCP-KMT
• Gene name: valosin containing protein lysine methyltransferase
• Alternate names: protein-lysine methyltransferase METTL21D, VCP lysine methyltransferase, methyltransferase like 21D, methyltransferase-like protein 21D, valosin containing protein lysine (K) methyltransferase,
• Gene location: 14q21.3 (50116571: 50100455)     Exons: 9     NC_000014.9
• OMIM: 615260

Protein Summary

• Protein general information: Q9H867  
  • Name: Protein lysine methyltransferase METTL21D (EC 2.1.1. ) (Methyltransferase like protein 21D) (VCP lysine methyltransferase) (VCP KMT) (Valosin containing protein lysine methyltransferase)
  • Length: 229  
  • Mass: 25807
• Sequence:

  MADTLESSLEDPLRSFVRVLEKRDGTVLRLQQYSSGGVGCVVWDAAIVLSKYLETPEFSGDGAHALSRRSVLELG
  SGTGAVGLMAATLGADVVVTDLEELQDLLKMNINMNKHLVTGSVQAKVLKWGEEIEGFPSPPDFILMADCIYYEE
  SLEPLLKTLKDISGFETCIICCYEQRTMGKNPEIEKKYFELLQLDFDFEKIPLEKHDEEYRSEDIHIIYIRKKKS
  KFPS

• Structural information:
  • Interpro: IPR019410  IPR029063  
  • PDB: 4LG1
  • PDBsum: 4LG1
  • STRING: ENSP00000379201
• Other Databases: GeneCards:  VCPKMT  Malacards:  VCPKMT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032259	methylation	IBA	biological process
GO:0018023	peptidyl-lysine trimethylation	IBA	biological process
GO:0016279	protein-lysine N-methyltransferase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0018022	peptidyl-lysine methylation	IBA	biological process
GO:0008168	methyltransferase activity	IBA	molecular function
GO:0018023	peptidyl-lysine trimethylation	IDA	biological process
GO:0016279	protein-lysine N-methyltransferase activity	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006479	protein methylation	TAS	biological process
GO:0016279	protein-lysine N-methyltransferase activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0032991	protein-containing complex	IDA	cellular component
GO:0016279	protein-lysine N-methyltransferase activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0032780	negative regulation of ATPase activity	IMP	biological process
GO:0018022	peptidyl-lysine methylation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0051117	ATPase binding	IPI	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)